Search Results

Overview

Uniprot IDQ9Y277
Protein NameNon-selective voltage-gated ion channel VDAC3
Gene NameVDAC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
109 IFVPNTGKKSGKLKA
115 GKKSGKLKASYKRDC
15 CDLGKAAKDVFNKGY
163 SFDTAKSKLSQNNFA
20 AAKDVFNKGYGFGMV
236 CRTSLSAKVNNASLI
266 LSALIDGKNFSAGGH
53 HAYTDTGKASGNLET
61 ASGNLETKYKVCNYG
63 GNLETKYKVCNYGLT

Function

Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity)

Protein Sequence

10 MCNTPTYCDL 20 GKAAKDVFNK 30 GYGFGMVKID 40 LKTKSCSGVE 50 FSTSGHAYTD 60 TGKASGNLET 70 KYKVCNYGLT 80 FTQKWNTDNT 90 LGTEISWENK 100 LAEGLKLTLD 110 TIFVPNTGKK 120 SGKLKASYKR 130 DCFSVGSNVD 140 IDFSGPTIYG 150 WAVLAFEGWL 160 AGYQMSFDTA 170 KSKLSQNNFA 180 LGYKAADFQL 190 HTHVNDGTEF 200 GGSIYQKVNE 210 KIETSINLAW 220 TAGSNNTRFG 230 IAAKYMLDCR 240 TSLSAKVNNA 250 SLIGLGYTQT 260 LRPGVKLTLS 270 ALIDGKNFSA 280 GGHKVGLGFE LEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0046930 pore complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0015288 porin activity
Molecular Function GO:0008308 voltage-gated monoatomic anion channel activity
Molecular Function GO:0005244 voltage-gated monoatomic ion channel activity
Biological Process GO:0015853 adenine transport
Biological Process GO:0120317 sperm mitochondrial sheath assembly
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.