Search Results
Overview
| Uniprot ID | Q9Y281 |
|---|---|
| Protein Name | Cofilin-2 |
| Gene Name | CFL2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | KMIYASSKDAIKKKF |
| 19 | IKVFNDMKVRKSSTQ |
| 22 | FNDMKVRKSSTQEEI |
| 44 | LFCLSDDKRQIIVEE |
Function
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0030043 | actin filament fragmentation |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0030836 | positive regulation of actin filament depolymerization |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.