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Overview

Uniprot IDQ9Y2A7
Protein NameNck-associated protein 1
Gene NameNCKAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
635 LLPKHCAKTISQAVN
643 TISQAVNKKSKKQTG
644 ISQAVNKKSKKQTGK

Function

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes

Protein Sequence

10 MSRSVLQPSQ 20 QKLAEKLTIL 30 NDRGVGMLTR 40 LYNIKKACGD 50 PKAKPSYLID 60 KNLESAVKFI 70 VRKFPAVETR 80 NNNQQLAQLQ 90 KEKSEILKNL 100 ALYYFTFVDV 110 MEFKDHVCEL 120 LNTIDVCQVF 130 FDITVNFDLT 140 KNYLDLIITY 150 TTLMILLSRI 160 EERKAIIGLY 170 NYAHEMTHGA 180 SDREYPRLGQ 190 MIVDYENPLK 200 KMMEEFVPHS 210 KSLSDALISL 220 QMVYPRRNLS 230 ADQWRNAQLL 240 SLISAPSTML 250 NPAQSDTMPC 260 EYLSLDAMEK 270 WIIFGFILCH 280 GILNTDATAL 290 NLWKLALQSS 300 SCLSLFRDEV 310 FHIHKAAEDL 320 FVNIRGYNKR 330 INDIRECKEA 340 AVSHAGSMHR 350 ERRKFLRSAL 360 KELATVLSDQ 370 PGLLGPKALF 380 VFMALSFARD 390 EIIWLLRHAD 400 NMPKKSADDF 410 IDKHIAELIF 420 YMEELRAHVR 430 KYGPVMQRYY 440 VQYLSGFDAV 450 VLNELVQNLS 460 VCPEDESIIM 470 SSFVNTMTSL 480 SVKQVEDGEV 490 FDFRGMRLDW 500 FRLQAYTSVS 510 KASLGLADHR 520 ELGKMMNTII 530 FHTKMVDSLV 540 EMLVETSDLS 550 IFCFYSRAFE 560 KMFQQCLELP 570 SQSRYSIAFP 580 LLCTHFMSCT 590 HELCPEERHH 600 IGDRSLSLCN 610 MFLDEMAKQA 620 RNLITDICTE 630 QCTLSDQLLP 640 KHCAKTISQA 650 VNKKSKKQTG 660 KKGEPEREKP 670 GVESMRKNRL 680 VVTNLDKLHT 690 ALSELCFSIN 700 YVPNMVVWEH 710 TFTPREYLTS 720 HLEIRFTKSI 730 VGMTMYNQAT 740 QEIAKPSELL 750 TSVRAYMTVL 760 QSIENYVQID 770 ITRVFNNVLL 780 QQTQHLDSHG 790 EPTITSLYTN 800 WYLETLLRQV 810 SNGHIAYFPA 820 MKAFVNLPTE 830 NELTFNAEEY 840 SDISEMRSLS 850 ELLGPYGMKF 860 LSESLMWHIS 870 SQVAELKKLV 880 VENVDVLTQM 890 RTSFDKPDQM 900 AALFKRLSSV 910 DSVLKRMTII 920 GVILSFRSLA 930 QEALRDVLSY 940 HIPFLVSSIE 950 DFKDHIPRET 960 DMKVAMNVYE 970 LSSAAGLPCE 980 IDPALVVALS 990 SQKSENISPE 1000 EEYKIACLLM 1010 VFVAVSLPTL 1020 ASNVMSQYSP 1030 AIEGHCNNIH 1040 CLAKAINQIA 1050 AALFTIHKGS 1060 IEDRLKEFLA 1070 LASSSLLKIG 1080 QETDKTTTRN 1090 RESVYLLLDM 1100 IVQESPFLTM 1110 DLLESCFPYV 1120 LLRNAYHAVY KQSVTSSA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0031258 lamellipodium membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0001726 ruffle
Cellular Component GO:0031209 SCAR complex
Biological Process GO:0006915 apoptotic process
Biological Process GO:0016477 cell migration
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0030031 cell projection assembly
Biological Process GO:0007417 central nervous system development
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
Biological Process GO:0010592 positive regulation of lamellipodium assembly
Biological Process GO:0016601 Rac protein signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.