Search Results
Overview
| Uniprot ID | Q9Y2D0 |
|---|---|
| Protein Name | Carbonic anhydrase 5B, mitochondrial |
| Gene Name | CA5B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 249 | SVTWIIKKQPVEVDH |
Function
Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3
Protein Sequence
10
MVVMNSLRVI
20
LQASPGKLLW
30
RKFQIPRFMP
40
ARPCSLYTCT
50
YKTRNRALHP
60
LWESVDLVPG
70
GDRQSPINIR
80
WRDSVYDPGL
90
KPLTISYDPA
100
TCLHVWNNGY
110
SFLVEFEDST
120
DKSVIKGGPL
130
EHNYRLKQFH
140
FHWGAIDAWG
150
SEHTVDSKCF
160
PAELHLVHWN
170
AVRFENFEDA
180
ALEENGLAVI
190
GVFLKLGKHH
200
KELQKLVDTL
210
PSIKHKDALV
220
EFGSFDPSCL
230
MPTCPDYWTY
240
SGSLTTPPLS
250
ESVTWIIKKQ
260
PVEVDHDQLE
270
QFRTLLFTSE
280
GEKEKRMVDN
290
FRPLQPLMNR
300
TVRSSFRHDY
310
VLNVQAKPKP
ATSQATP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004089 | carbonate dehydratase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.