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Overview

Uniprot ID	Q9Y2D5
Protein Name	PALM2-AKAP2 fusion protein
Gene Name	PALM2AKAP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
464	IRSQAVKKNPGIAAK
983	STQSPRTKNAPSLPS

Function

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton

Protein Sequence

10 MAEAELHKER 20 LQAIAEKRKR 30 QTEIEGKRQQ 40 LDEQILLLQH 50 SKSKVLREKW 60 LLQGIPAGTA 70 EEEEARRRQS 80 EEDEFRVKQL 90 EDNIQRLEQE 100 IQTLESEESQ 110 ISAKEQIILE 120 KLKETEKSFK 130 DFQKGFSSTD 140 GDAVNYISSQ 150 LPDLPILCSR 160 TAEPSPGQDG 170 TSRAAGVGWE 180 NVLLKEGESA 190 SNATETSGPD 200 MTIKKPPQLS 210 EDDIWLKSEG 220 DNYSATLLEP 230 AASSLSPDHK 240 NMEIEVSVAE 250 CKSVPGITST 260 PHPMDHPSAF 270 YSPPHNGLLT 280 DHHESLDNDV 290 AREIRYLDEV 300 LEANCCDSAV 310 DGTYNGTSSP 320 EPGAVVLVGG 330 LSPPVHEATQ 340 PEPTERTASR 350 QAPPHIELSN 360 SSPDPMAEAE 370 RTNGHSPSQP 380 RDALGDSLQV 390 PVSPSSTTSS 400 RCSSRDGEFT 410 LTTLKKEAKF 420 ELRAFHEDKK 430 PSKLFEDDEH 440 EKEQYCIRKV 450 RPSEEMLELE 460 KERRELIRSQ 470 AVKKNPGIAA 480 KWWNPPQEKT 490 IEEQLDEEHL 500 ESHKKYKERK 510 ERRAQQEQLL 520 LQKQLQQQQQ 530 QPPSQLCTAP 540 ASSHERASMI 550 DKAKEDIVTE 560 QIDFSAARKQ 570 FQLMENSRQA 580 VAKGQSTPRL 590 FSIKPFYRPL 600 GSVNSDKPLT 610 NPRPPSVGGP 620 PEDSGASAAK 630 GQKSPGALET 640 PSAAGSQGNT 650 ASQGKEGPYS 660 EPSKRGPLSK 670 LWAEDGEFTS 680 ARAVLTVVKD 690 DDHGILDQFS 700 RSVNVSLTQE 710 ELDSGLDELS 720 VRSQDTTVLE 730 TLSNDFSMDN 740 ISDSGASNET 750 TNALQENSLA 760 DFSLPQTPQT 770 DNPSEGRGEG 780 VSKSFSDHGF 790 YSPSSTLGDS 800 PLVDDPLEYQ 810 AGLLVQNAIQ 820 QAIAEQVDKA 830 VSKTSRDGAE 840 QQGPEATVEE 850 AEAAAFGSEK 860 PQSMFEPPQV 870 SSPVQEKRDV 880 LPKILPAEDR 890 ALRERGPPQP 900 LPAVQPSGPI 910 NMEETRPEGS 920 YFSKYSEAAE 930 LRSTASLLAT 940 QESDVMVGPF 950 KLRSRKQRTL 960 SMIEEEIRAA 970 QEREEELKRQ 980 RQVLQSTQSP 990 RTKNAPSLPS 1000 RTCYKTAPGK 1010 IEKVKPPPSP 1020 TTEGPSLQPD 1030 LAPEEAAGTQ 1040 RPKNLMQTLM 1050 EDYETHKSKR 1060 RERMDDSSYT 1070 SKLLSCKVTS 1080 EVLEATRVNR 1090 RKSALALRWE 1100 AGIYANQEEE DNE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098552	side of membrane
Molecular Function	GO:0051018	protein kinase A binding
Biological Process	GO:0008360	regulation of cell shape

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.