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Overview

Uniprot IDQ9Y2D9
Protein NameZinc finger protein 652
Gene NameZNF652
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
184 KKEKIVEKVSVTQRR

Function

DNA-binding transcription repressor that acts together with CBFA2T2 to repress expression of target genes, such as TCF12 (PubMed:16966434, PubMed:18456661, PubMed:21678463). Specifically binds the DNA consensus sequence 5'-CGAAAGGGTTAAT-3' (PubMed:18456661, PubMed:21678463)

Protein Sequence

10 MSHTASSCQE 20 LVENCAVHVA 30 GMAQEDSRRG 40 QVPSSFYHGA 50 NQELDLSTKV 60 YKRESGSPYS 70 VLVDTKMSKP 80 HLHETEEQPY 90 FRETRAVSDV 100 HAVKEDRENS 110 DDTEEEEEEV 120 SYKREQIIVE 130 VNLNNQTLNV 140 SKGEKGVSSQ 150 SKETPVLKTS 160 SEEEEEESEE 170 EATDDSNDYG 180 ENEKQKKKEK 190 IVEKVSVTQR 200 RTRRAASVAA 210 ATTSPTPRTT 220 RGRRKSVEPP 230 KRKKRATKEP 240 KAPVQKAKCE 250 EKETLTCEKC 260 PRVFNTRWYL 270 EKHMNVTHRR 280 MQICDKCGKK 290 FVLESELSLH 300 QQTDCEKNIQ 310 CVSCNKSFKK 320 LWSLHEHIKI 330 VHGYAEKKFS 340 CEICEKKFYT 350 MAHVRKHMVA 360 HTKDMPFTCE 370 TCGKSFKRSM 380 SLKVHSLQHS 390 GEKPFRCENC 400 DERFQYKYQL 410 RSHMSIHIGH 420 KQFMCQWCGK 430 DFNMKQYFDE 440 HMKTHTGEKP 450 FICEICGKSF 460 TSRPNMKRHR 470 RTHTGEKPYP 480 CDVCGQRFRF 490 SNMLKAHKEK 500 CFRVTSPVNV 510 PPAVQIPLTT 520 SPATPVPSVV 530 NTATTPTPPI 540 NMNPVSTLPP 550 RPIPHPFSHL 560 HIHPHPHHPH 570 HLPIPPVPHL 580 PPPPALFKSE 590 PLNHRGQSED 600 NFLRHLAEKN SSAQHH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.