Search Results

Overview

Uniprot IDQ9Y2F5
Protein NameLittle elongation complex subunit 1
Gene NameICE1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1569 DQSNKPVKTSASSRV
565 SPKSEFTKWTRINEI

Function

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780)

Protein Sequence

10 MMPGETHSAA 20 PGTAADLSRC 30 QGCASLQQNL 40 NEYVEALITL 50 KQKIINTDNL 60 LTEYQKKCDE 70 LQFARRENSN 80 LHHQVEEMLQ 90 KISPLQKCQE 100 ELGSLKAELE 110 EKKSSLKLYQ 120 DTHQEYARVK 130 EECLKSDAQK 140 KKLEAKVKKL 150 QEAAVKQTQD 160 FKQLRNEKKI 170 LEKEFKKTQE 180 RLDEFSKQKN 190 EKELRHIGTQ 200 ISSDSYGSID 210 KRKVKLLLKE 220 LWLCVNTTHR 230 LPGEGSRCVP 240 EKPAKAITSS 250 RVPGEDGTLP 260 PTQGSPLRTS 270 NVQTCLTKLS 280 MEIKEDFLCQ 290 NVEKQSSSGT 300 NCSSDHVFNE 310 NGNLEVLVQS 320 HRDGGSTEFV 330 DHDHFFDEDL 340 QAAIDFFKLP 350 PPLLSPVPSP 360 PPMSSPHPGS 370 LPSSFAPETY 380 FGEYTDSSDN 390 DSVQLRNSAE 400 CVSEDDTTES 410 QNYFGSLRKN 420 KGSGTWEEKP 430 KSHEAIQALN 440 TWEVNKVTTS 450 GLETFTATLR 460 ESSATHSLVG 470 EKHWTTASRS 480 MSDRKRDILH 490 ETKTQMEVRE 500 MDKSVQTEKT 510 IHKLTRGLCI 520 ERLSASPAQE 530 KEAAPGKSEL 540 CSSPLGKRPL 550 NELMESEGKT 560 VLSKMMGSPK 570 SEFTKWTRIN 580 EITSEPDRIT 590 VSGHFHRLSR 600 ELEKEKEDTQ 610 GFTLGESPES 620 EDDDSGDGMD 630 VAGLDIETSF 640 SSSSTLVALS 650 VGSNPQSSSG 660 LDCGNDTDIT 670 TKVFSTEPHH 680 SEHKLQTKTL 690 NTLHLQSEPP 700 ECSIGGNNLE 710 NSLCALSPEL 720 GASNFNDQKS 730 SGIEYTKVVK 740 GLTKIHSLPR 750 SVFMKATKDG 760 QCESQDPRIE 770 LTLNKPDFTS 780 LIGSQAALIK 790 SGLGFVKSTS 800 WHHSDLLRKG 810 GEESLRAKSE 820 HEQKTSHQLQ 830 KAMPFLQNRG 840 PTPKPDLLRE 850 NNNPVEFKTT 860 ASVLPNQVSV 870 ITKQTRPEKV 880 QSAKLEHLRP 890 HRVEPTLVTE 900 NSGNKTGMST 910 VAKCDGERDD 920 TTQNITEVAA 930 VKSISPEVSA 940 SRRKLDFNSP 950 GGSSPVENSD 960 CSTNSRLSFS 970 PENILIQNQD 980 IVREAAVQGD 990 GQKQRQPQAT 1000 DLDSSGTHGS 1010 EMLPATEVTV 1020 SGGFSVEETS 1030 CGDTGRSGGE 1040 ALAVANDSTS 1050 TPQNANGLWK 1060 LKSTTPGGAL 1070 PECFGTTDTT 1080 FSSAFCRKHG 1090 ETQDTSQSSL 1100 PGTLHCYTGI 1110 REGGDDTEVE 1120 SEAFSCSEGS 1130 EQQDAPDDSQ 1140 KNLGDTDAAV 1150 AEVRPSLEVG 1160 YLTSALQDFN 1170 ISTFSELDRL 1180 STSEVVMFLE 1190 SCQLGDYSSG 1200 DSVSECSSKG 1210 TLSKEMNKEL 1220 KASEIGEKYR 1230 KQPCEEETLG 1240 TCEEWIESEE 1250 DDYSLKNTSQ 1260 LTQCSLETLS 1270 EVLTKIRQEL 1280 QTNSEDCNGK 1290 DTGSLLLLNV 1300 NNNMTTENLK 1310 EKSPFRETTG 1320 SSSHASEPTP 1330 QAAALDTEGS 1340 SPISGMPQNE 1350 NPQSRPEARS 1360 DAGRQTDGGE 1370 EDLPEPVEPS 1380 ALCSDSVMEP 1390 SIEQSSNCEA 1400 ETTFQCQIAT 1410 VTSEVINVLI 1420 NKDQNLVIEK 1430 GDNWTIISGV 1440 AVLPHVDQVT 1450 LCDIPGDIPI 1460 SQDQGELEAG 1470 CIPVTSAEKS 1480 PEASHTGPAF 1490 QEAPCGNNLS 1500 CPQEDVSSSG 1510 QSTNFDKSRL 1520 RNRPVKPSIW 1530 ISSQIYDQNF 1540 ETQIVASDHT 1550 YYNSKLEPSG 1560 KNKNRSKISN 1570 KDQSNKPVKT 1580 SASSRVETHQ 1590 SEVAQSFSGE 1600 KANTKTQRSQ 1610 TQTILANADT 1620 STPTDCSPDT 1630 LSKIRQEVGP 1640 PLPPLLAPLI 1650 ATPPRTSQPL 1660 SPLISSSSPS 1670 SPASPVGQVS 1680 PFRETPVPPA 1690 MSPWPEDPRR 1700 ASPPDPSPSP 1710 SAASASERVV 1720 PSPLQFCAAT 1730 PKHALPVPGR 1740 LPPCASGHAA 1750 VGGPQENSVK 1760 ILDTMYPELS 1770 ARARTLNILK 1780 GNIQLTRGPP 1790 ADCKNLPGPA 1800 SAMIGFKTIT 1810 SAATAFVKTG 1820 SSSGGDCNQD 1830 KSRDLGTQQD 1840 SSGKRTLSTS 1850 TLRSAKRLRL 1860 DTGSPEPETR 1870 GVTAEGIHKN 1880 LPGNLPPAEV 1890 ATTNEERSCS 1900 SPAVSAVSQL 1910 PLSPKETVES 1920 HDKAIANALK 1930 KIAEFSFDLL 1940 PVIRSHVYVG 1950 NISKKPVMRD 1960 QEKEVVYEFS 1970 TTKKHLAECL 1980 LHSILSELKI 1990 QKISMDHNYI 2000 HALCRVYVGI 2010 CRQLGDLERA 2020 RLFCYSLLKE 2030 DFPESEKLTL 2040 FIANMWHDIF 2050 LSQSVINKAM 2060 QLVARQRAKG 2070 EVLNCLRAFL 2080 NWEKNAPVDV 2090 GFMVSKLLLT 2100 IQLCPKTEFQ 2110 PSEKFGEDLS 2120 DNTWEYIFAI 2130 DLLCCHQKWI 2140 WTHDNIISKE 2150 LWPVMDKWIK 2160 YRKGHANIAY 2170 TPDIIIASIL 2180 RLIGRLGQLG 2190 LKEGFPSAVK 2200 NISSVIGMFI 2210 QHAHDEDIPW 2220 GIQLAAVYAL 2230 CDLSPSNPAE 2240 ISKILEAWRR 2250 EASKSVPSAI 2260 VSCLEEVSAL STEELG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Biological Process GO:0042795 snRNA transcription by RNA polymerase II
Biological Process GO:0042796 snRNA transcription by RNA polymerase III
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0035363 histone locus body
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0008023 transcription elongation factor complex
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:1905382 positive regulation of snRNA transcription by RNA polymerase II
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.