Search Results

Overview

Uniprot ID	Q9Y2H0
Protein Name	Disks large-associated protein 4
Gene Name	DLGAP4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
754	AGPRQAPKIAQIKRN

Function

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane

Protein Sequence

10 MKGLGDSRPR 20 HLSDSLDPPH 30 EPLFAGTDRN 40 PYLLSPTEAF 50 AREARFPGQN 60 TLPGDGLFPL 70 NNQLPPPSST 80 FPRIHYNSHF 90 EVPEESPFPS 100 HAQATKINRL 110 PANLLDQFEK 120 QLPIHRDGFS 130 TLQFPRGEAK 140 ARGESPGRIR 150 HLVHSVQRLF 160 FTKAPSLEGT 170 AGKVGGNGSK 180 KGGMEDGKGR 190 RAKSKERAKA 200 GEPKRRSRSN 210 ISGWWSSDDN 220 LDGEAGAFRS 230 SGPASGLMTL 240 GRQAERSQPR 250 YFMHAYNTIS 260 GHMLKTTKNN 270 TTELTAPPPP 280 PAPPATCPSL 290 GVGTDTNYVK 300 RGSWSTLTLS 310 HAHEVCQKTS 320 ATLDKSLLKS 330 KSCHQGLAYH 340 YLQVPGGGGE 350 WSTTLLSPRE 360 TDAAAEGPIP 370 CRRMRSGSYI 380 KAMGDEDSDE 390 SGGSPKPSPK 400 TAARRQSYLR 410 ATQQSLGEQS 420 NPRRSLDRLD 430 SVDMLLPSKC 440 PSWEEDYTPV 450 SDSLNDSSCI 460 SQIFGQASLI 470 PQLFGHEQQV 480 REAELSDQYE 490 AACESACSEA 500 ESTAAETLDL 510 PLPSYFRSRS 520 HSYLRAIQAG 530 CSQEEDSVSL 540 QSLSPPPSTG 550 SLSNSRTLPS 560 SSCLVAYKKT 570 PPPVPPRTTS 580 KPFISVTVQS 590 STESAQDTYL 600 DSQDHKSEVT 610 SQSGLSNSSD 620 SLDSSTRPPS 630 VTRGGVAPAP 640 EAPEPPPKHA 650 ALKSEQGTLT 660 SSESHPEAAP 670 KRKLSSIGIQ 680 VDCIQPVPKE 690 EPSPATKFQS 700 IGVQVEDDWR 710 SSVPSHSMSS 720 RRDTDSDTQD 730 ANDSSCKSSE 740 RSLPDCTPHP 750 NSISIDAGPR 760 QAPKIAQIKR 770 NLSYGDNSDP 780 ALEASSLPPP 790 DPWLETSSSS 800 PAEPAQPGAC 810 RRDGYWFLKL 820 LQAETERLEG 830 WCCQMDKETK 840 ENNLSEEVLG 850 KVLSAVGSAQ 860 LLMSQKFQQF 870 RGLCEQNLNP 880 DANPRPTAQD 890 LAGFWDLLQL 900 SIEDISMKFD 910 ELYHLKANSW 920 QLVETPEKRK 930 EEKKPPPPVP 940 KKPAKSKPAV 950 SRDKASDASD 960 KQRQEARKRL 970 LAAKRAASVR 980 QNSATESADS 990 IEIYVPEAQT RL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0098981	cholinergic synapse
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0031594	neuromuscular junction
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0099572	postsynaptic specialization
Molecular Function	GO:0060090	molecular adaptor activity
Biological Process	GO:0099010	modification of postsynaptic structure
Biological Process	GO:0050804	modulation of chemical synaptic transmission
Biological Process	GO:0090128	regulation of synapse maturation
Biological Process	GO:0023052	signaling

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.