Search Results

Overview

Uniprot ID	Q9Y2J0
Protein Name	Rabphilin-3A
Gene Name	RPH3A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
433	GLADPYVKLHLLPGA
505	RFSLKKLKPNQRKNF

Function

Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity)

Protein Sequence

10 MTDTVFSNSS 20 NRWMYPSDRP 30 LQSNDKEQLQ 40 AGWSVHPGGQ 50 PDRQRKQEEL 60 TDEEKEIINR 70 VIARAEKMEE 80 MEQERIGRLV 90 DRLENMRKNV 100 AGDGVNRCIL 110 CGEQLGMLGS 120 ACVVCEDCKK 130 NVCTKCGVET 140 NNRLHSVWLC 150 KICIEQREVW 160 KRSGAWFFKG 170 FPKQVLPQPM 180 PIKKTKPQQP 190 VSEPAAPEQP 200 APEPKHPARA 210 PARGDSEDRR 220 GPGQKTGPDP 230 ASAPGRGNYG 240 PPVRRASEAR 250 MSSSSRDSES 260 WDHSGGAGDS 270 SRSPAGLRRA 280 NSVQASRPAP 290 GSVQSPAPPQ 300 PGQPGTPGGS 310 RPGPGPAGRF 320 PDQKPEVAPS 330 DPGTTAPPRE 340 ERTGGVGGYP 350 AVGAREDRMS 360 HPSGPYSQAS 370 AAAPQPAAAR 380 QPPPPEEEEE 390 EANSYDSDEA 400 TTLGALEFSL 410 LYDQDNSSLQ 420 CTIIKAKGLK 430 PMDSNGLADP 440 YVKLHLLPGA 450 SKSNKLRTKT 460 LRNTRNPIWN 470 ETLVYHGITD 480 EDMQRKTLRI 490 SVCDEDKFGH 500 NEFIGETRFS 510 LKKLKPNQRK 520 NFNICLERVI 530 PMKRAGTTGS 540 ARGMALYEEE 550 QVERVGDIEE 560 RGKILVSLMY 570 STQQGGLIVG 580 IIRCVHLAAM 590 DANGYSDPFV 600 KLWLKPDMGK 610 KAKHKTQIKK 620 KTLNPEFNEE 630 FFYDIKHSDL 640 AKKSLDISVW 650 DYDIGKSNDY 660 IGGCQLGISA 670 KGERLKHWYE 680 CLKNKDKKIE 690 RWHQLQNENH VSSD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0019898	extrinsic component of membrane
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0045211	postsynaptic membrane
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0030141	secretory granule
Cellular Component	GO:0045202	synapse
Cellular Component	GO:0008021	synaptic vesicle
Cellular Component	GO:0030672	synaptic vesicle membrane
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0005544	calcium-dependent phospholipid binding
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding
Molecular Function	GO:0042301	phosphate ion binding
Molecular Function	GO:1901981	phosphatidylinositol phosphate binding
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0008430	selenium binding
Molecular Function	GO:0031267	small GTPase binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0045956	positive regulation of calcium ion-dependent exocytosis
Biological Process	GO:0016082	synaptic vesicle priming

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.