Search Results

Overview

Uniprot IDQ9Y2J2
Protein NameBand 4.1-like protein 3
Gene NameEPB41L3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 KLSRSPLKIVKKPKS
1058 QALAQAIKEAKEQHP
261 RFAPNHTKELEDKVI
397 LLPEAPPKKFLTLGS
472 ITTVTPEKKAEEERD
75 EFAARAAKQLEYQQL
807 SLLESARKPTEFIGG
829 WVQKMETKTESSGIE
892 AFTGIKGKEGSALTE
973 VKLEISTKEVPVVHT

Function

Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5

Protein Sequence

10 MTTESGSDSE 20 SKPDQEAEPQ 30 EAAGAQGRAG 40 APVPEPPKEE 50 QQQALEQFAA 60 AAAHSTPVRR 70 EVTDKEQEFA 80 ARAAKQLEYQ 90 QLEDDKLSQK 100 SSSSKLSRSP 110 LKIVKKPKSM 120 QCKVILLDGS 130 EYTCDVEKRS 140 RGQVLFDKVC 150 EHLNLLEKDY 160 FGLTYRDAEN 170 QKNWLDPAKE 180 IKKQVRSGAW 190 HFSFNVKFYP 200 PDPAQLSEDI 210 TRYYLCLQLR 220 DDIVSGRLPC 230 SFVTLALLGS 240 YTVQSELGDY 250 DPDECGSDYI 260 SEFRFAPNHT 270 KELEDKVIEL 280 HKSHRGMTPA 290 EAEMHFLENA 300 KKLSMYGVDL 310 HHAKDSEGVE 320 IMLGVCASGL 330 LIYRDRLRIN 340 RFAWPKVLKI 350 SYKRNNFYIK 360 IRPGEFEQFE 370 STIGFKLPNH 380 RAAKRLWKVC 390 VEHHTFFRLL 400 LPEAPPKKFL 410 TLGSKFRYSG 420 RTQAQTRRAS 430 ALIDRPAPYF 440 ERSSSKRYTM 450 SRSLDGEVGT 460 GQYATTKGIS 470 QTNLITTVTP 480 EKKAEEERDE 490 EEDKRRKGEE 500 VTPISAIRHE 510 GKSPGLGTDS 520 CPLSPPSTHC 530 APTSPTELRR 540 RCKENDCKLP 550 GYEPSRAEHL 560 PGEPALDSDG 570 PGRPYLGDQD 580 VAFSYRQQTG 590 KGTTLFSFSL 600 QLPESFPSLL 610 DDDGYLSFPN 620 LSETNLLPQS 630 LQHYLPIRSP 640 SLVPCFLFIF 650 FFLLSASFSV 660 PYALTLSFPL 670 ALCLCYLEPK 680 AASLSASLDN 690 DPSDSSEEET 700 DSERTDTAAD 710 GETTATESDQ 720 EEDAELKAQE 730 LEKTQDDLMK 740 HQTNISELKR 750 TFLETSTDTA 760 VTNEWEKRLS 770 TSPVRLAARQ 780 EDAPMIEPLV 790 PEETKQSSGE 800 KLMDGSEIFS 810 LLESARKPTE 820 FIGGVTSTSQ 830 SWVQKMETKT 840 ESSGIETEPT 850 VHHLPLSTEK 860 VVQETVLVEE 870 RRVVHASGDA 880 SYSAGDSGDA 890 AAQPAFTGIK 900 GKEGSALTEG 910 AKEEGGEEVA 920 KAVLEQEETA 930 AASRERQEEQ 940 SAAIHISETL 950 EQKPHFESST 960 VKTETISFGS 970 VSPGGVKLEI 980 STKEVPVVHT 990 ETKTITYESS 1000 QVDPGTDLEP 1010 GVLMSAQTIT 1020 SETTSTTTTT 1030 HITKTVKGGI 1040 SETRIEKRIV 1050 ITGDADIDHD 1060 QALAQAIKEA 1070 KEQHPDMSVT 1080 KVVVHKETEI TPEDGED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0044224 juxtaparanode region of axon
Cellular Component GO:0033270 paranode region of axon
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Molecular Function GO:0003779 actin binding
Molecular Function GO:0106006 cytoskeletal protein-membrane anchor activity
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0006915 apoptotic process
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0030865 cortical cytoskeleton organization
Biological Process GO:0043217 myelin maintenance
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0030913 paranodal junction assembly
Biological Process GO:0071205 protein localization to juxtaparanode region of axon
Biological Process GO:0002175 protein localization to paranode region of axon
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.