Search Results
Overview
| Uniprot ID | Q9Y2J8 |
|---|---|
| Protein Name | Protein-arginine deiminase type-2 |
| Gene Name | PADI2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 524 | GLGGMSSKRITINKI |
Function
Catalyzes the deimination of arginine residues of proteins
Protein Sequence
10
MLRERTVRLQ
20
YGSRVEAVYV
30
LGTYLWTDVY
40
SAAPAGAQTF
50
SLKHSEHVWV
60
EVVRDGEAEE
70
VATNGKQRWL
80
LSPSTTLRVT
90
MSQASTEASS
100
DKVTVNYYDE
110
EGSIPIDQAG
120
LFLTAIEISL
130
DVDADRDGVV
140
EKNNPKKASW
150
TWGPEGQGAI
160
LLVNCDRETP
170
WLPKEDCRDE
180
KVYSKEDLKD
190
MSQMILRTKG
200
PDRLPAGYEI
210
VLYISMSDSD
220
KVGVFYVENP
230
FFGQRYIHIL
240
GRRKLYHVVK
250
YTGGSAELLF
260
FVEGLCFPDE
270
GFSGLVSIHV
280
SLLEYMAQDI
290
PLTPIFTDTV
300
IFRIAPWIMT
310
PNILPPVSVF
320
VCCMKDNYLF
330
LKEVKNLVEK
340
TNCELKVCFQ
350
YLNRGDRWIQ
360
DEIEFGYIEA
370
PHKGFPVVLD
380
SPRDGNLKDF
390
PVKELLGPDF
400
GYVTREPLFE
410
SVTSLDSFGN
420
LEVSPPVTVN
430
GKTYPLGRIL
440
IGSSFPLSGG
450
RRMTKVVRDF
460
LKAQQVQAPV
470
ELYSDWLTVG
480
HVDEFMSFVP
490
IPGTKKFLLL
500
MASTSACYKL
510
FREKQKDGHG
520
EAIMFKGLGG
530
MSSKRITINK
540
ILSNESLVQE
550
NLYFQRCLDW
560
NRDILKKELG
570
LTEQDIIDLP
580
ALFKMDEDHR
590
ARAFFPNMVN
600
MIVLDKDLGI
610
PKPFGPQVEE
620
ECCLEMHVRG
630
LLEPLGLECT
640
FIDDISAYHK
650
FLGEVHCGTN
660
VRRKPFTFKW
WHMVP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0140794 | histone arginine deiminase activity |
| Molecular Function | GO:0140798 | histone H3R26 arginine deiminase activity |
| Molecular Function | GO:0030331 | nuclear estrogen receptor binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004668 | protein-arginine deiminase activity |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0030520 | estrogen receptor signaling pathway |
| Biological Process | GO:0070100 | negative regulation of chemokine-mediated signaling pathway |
| Biological Process | GO:1901624 | negative regulation of lymphocyte chemotaxis |
| Biological Process | GO:0021762 | substantia nigra development |
| Biological Process | GO:0045815 | transcription initiation-coupled chromatin remodeling |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.