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Overview

Uniprot IDQ9Y2K1
Protein NameZinc finger and BTB domain-containing protein 1
Gene NameZBTB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
200 CKKSSVSKLSTPKER
524 QINSIQKKQLFKHSA

Function

Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity)

Protein Sequence

10 MAKPSHSSYV 20 LQQLNNQREW 30 GFLCDCCIAI 40 DDIYFQAHKA 50 VLAACSSYFR 60 MFFMNHQHST 70 AQLNLSNMKI 80 SAECFDLILQ 90 FMYLGKIMTA 100 PSSFEQFKVA 110 MNYLQLYNVP 120 DCLEDIQDAD 130 CSSSKCSSSA 140 SSKQNSKMIF 150 GVRMYEDTVA 160 RNGNEANRWC 170 AEPSSTVNTP 180 HNREADEESL 190 QLGNFPEPLF 200 DVCKKSSVSK 210 LSTPKERVSR 220 RFGRSFTCDS 230 CGFGFSCEKL 240 LDEHVLTCTN 250 RHLYQNTRSY 260 HRIVDIRDGK 270 DSNIKAEFGE 280 KDSSKTFSAQ 290 TDKYRGDTSQ 300 AADDSASTTG 310 SRKSSTVESE 320 IASEEKSRAA 330 ERKRIIIKME 340 PEDIPTDELK 350 DFNIIKVTDK 360 DCNESTDNDE 370 LEDEPEEPFY 380 RYYVEEDVSI 390 KKSGRKTLKP 400 RMSVSADERG 410 GLENMRPPNN 420 SSPVQEDAEN 430 ASCELCGLTI 440 TEEDLSSHYL 450 AKHIENICAC 460 GKCGQILVKG 470 RQLQEHAQRC 480 GEPQDLTMNG 490 LGNTEEKMDL 500 EENPDEQSEI 510 RDMFVEMLDD 520 FRDNHYQINS 530 IQKKQLFKHS 540 ACPFRCPNCG 550 QRFETENLVV 560 EHMSSCLDQD 570 MFKSAIMEEN 580 ERDHRRKHFC 590 NLCGKGFYQR 600 CHLREHYTVH 610 TKEKQFVCQT 620 CGKQFLRERQ 630 LRLHNDMHKG 640 MARYVCSICD 650 QGNFRKHDHV 660 RHMISHLSAG 670 ETICQVCFQI 680 FPNNEQLEQH 690 MDVHLYTCGI 700 CGAKFNLRKD 710 MRSHYNAKHL KRT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair
Biological Process GO:0045087 innate immune response
Biological Process GO:0042789 mRNA transcription by RNA polymerase II
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032825 positive regulation of natural killer cell differentiation
Biological Process GO:2000176 positive regulation of pro-T cell differentiation
Biological Process GO:0045582 positive regulation of T cell differentiation
Biological Process GO:0002711 positive regulation of T cell mediated immunity
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0001817 regulation of cytokine production
Biological Process GO:0002682 regulation of immune system process
Biological Process GO:0048538 thymus development
Biological Process GO:0019985 translesion synthesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.