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Overview

Uniprot IDQ9Y2K7
Protein NameLysine-specific demethylase 2A
Gene NameKDM2A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
791 KELSEVEKAKIRGSY

Function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310)

Protein Sequence

10 MEPEEERIRY 20 SQRLRGTMRR 30 RYEDDGISDD 40 EIEGKRTFDL 50 EEKLHTNKYN 60 ANFVTFMEGK 70 DFNVEYIQRG 80 GLRDPLIFKN 90 SDGLGIKMPD 100 PDFTVNDVKM 110 CVGSRRMVDV 120 MDVNTQKGIE 130 MTMAQWTRYY 140 ETPEEEREKL 150 YNVISLEFSH 160 TRLENMVQRP 170 STVDFIDWVD 180 NMWPRHLKES 190 QTESTNAILE 200 MQYPKVQKYC 210 LMSVRGCYTD 220 FHVDFGGTSV 230 WYHIHQGGKV 240 FWLIPPTAHN 250 LELYENWLLS 260 GKQGDIFLGD 270 RVSDCQRIEL 280 KQGYTFVIPS 290 GWIHAVYTPT 300 DTLVFGGNFL 310 HSFNIPMQLK 320 IYNIEDRTRV 330 PNKFRYPFYY 340 EMCWYVLERY 350 VYCITNRSHL 360 TKEFQKESLS 370 MDLELNGLES 380 GNGDEEAVDR 390 EPRRLSSRRS 400 VLTSPVANGV 410 NLDYDGLGKT 420 CRSLPSLKKT 430 LAGDSSSDCS 440 RGSHNGQVWD 450 PQCAPRKDRQ 460 VHLTHFELEG 470 LRCLVDKLES 480 LPLHKKCVPT 490 GIEDEDALIA 500 DVKILLEELA 510 NSDPKLALTG 520 VPIVQWPKRD 530 KLKFPTRPKV 540 RVPTIPITKP 550 HTMKPAPRLT 560 PVRPAAASPI 570 VSGARRRRVR 580 CRKCKACVQG 590 ECGVCHYCRD 600 MKKFGGPGRM 610 KQSCVLRQCL 620 APRLPHSVTC 630 SLCGEVDQNE 640 ETQDFEKKLM 650 ECCICNEIVH 660 PGCLQMDGEG 670 LLNEELPNCW 680 ECPKCYQEDS 690 SEKAQKRKME 700 ESDEEAVQAK 710 VLRPLRSCDE 720 PLTPPPHSPT 730 SMLQLIHDPV 740 SPRGMVTRSS 750 PGAGPSDHHS 760 ASRDERFKRR 770 QLLRLQATER 780 TMVREKENNP 790 SGKKELSEVE 800 KAKIRGSYLT 810 VTLQRPTKEL 820 HGTSIVPKLQ 830 AITASSANLR 840 HSPRVLVQHC 850 PARTPQRGDE 860 EGLGGEEEEE 870 EEEEEEDDSA 880 EEGGAARLNG 890 RGSWAQDGDE 900 SWMQREVWMS 910 VFRYLSRREL 920 CECMRVCKTW 930 YKWCCDKRLW 940 TKIDLSRCKA 950 IVPQALSGII 960 KRQPVSLDLS 970 WTNISKKQLT 980 WLVNRLPGLK 990 DLLLAGCSWS 1000 AVSALSTSSC 1010 PLLRTLDLRW 1020 AVGIKDPQIR 1030 DLLTPPADKP 1040 GQDNRSKLRN 1050 MTDFRLAGLD 1060 ITDATLRLII 1070 RHMPLLSRLD 1080 LSHCSHLTDQ 1090 SSNLLTAVGS 1100 STRYSLTELN 1110 MAGCNKLTDQ 1120 TLIYLRRIAN 1130 VTLIDLRGCK 1140 QITRKACEHF 1150 ISDLSINSLY 1160 CLSDEKLIQK IS

Gene Ontology

Classification GO ID Description
Biological Process GO:0042752 regulation of circadian rhythm
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0032452 histone demethylase activity
Molecular Function GO:0051864 histone H3K36 demethylase activity
Molecular Function GO:0140680 histone H3K36me/H3K36me2 demethylase activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0045322 unmethylated CpG binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0010944 negative regulation of transcription by competitive promoter binding
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Reference

PMID: N/A