Search Results
Overview
| Uniprot ID | Q9Y2Q0 |
|---|---|
| Protein Name | Phospholipid-transporting ATPase IA |
| Gene Name | ATP8A1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 704 | HSCKLLKKNMGMIVI |
Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity)
Protein Sequence
10
MPTMRRTVSE
20
IRSRAEGYEK
30
TDDVSEKTSL
40
ADQEEVRTIF
50
INQPQLTKFC
60
NNHVSTAKYN
70
IITFLPRFLY
80
SQFRRAANSF
90
FLFIALLQQI
100
PDVSPTGRYT
110
TLVPLLFILA
120
VAAIKEIIED
130
IKRHKADNAV
140
NKKQTQVLRN
150
GAWEIVHWEK
160
VAVGEIVKVT
170
NGEHLPADLI
180
SLSSSEPQAM
190
CYIETSNLDG
200
ETNLKIRQGL
210
PATSDIKDVD
220
SLMRISGRIE
230
CESPNRHLYD
240
FVGNIRLDGH
250
GTVPLGADQI
260
LLRGAQLRNT
270
QWVHGIVVYT
280
GHDTKLMQNS
290
TSPPLKLSNV
300
ERITNVQILI
310
LFCILIAMSL
320
VCSVGSAIWN
330
RRHSGKDWYL
340
NLNYGGASNF
350
GLNFLTFIIL
360
FNNLIPISLL
370
VTLEVVKFTQ
380
AYFINWDLDM
390
HYEPTDTAAM
400
ARTSNLNEEL
410
GQVKYIFSDK
420
TGTLTCNVMQ
430
FKKCTIAGVA
440
YGHVPEPEDY
450
GCSPDEWQNS
460
QFGDEKTFSD
470
SSLLENLQNN
480
HPTAPIICEF
490
LTMMAVCHTA
500
VPEREGDKII
510
YQAASPDEGA
520
LVRAAKQLNF
530
VFTGRTPDSV
540
IIDSLGQEER
550
YELLNVLEFT
560
SARKRMSVIV
570
RTPSGKLRLY
580
CKGADTVIYD
590
RLAETSKYKE
600
ITLKHLEQFA
610
TEGLRTLCFA
620
VAEISESDFQ
630
EWRAVYQRAS
640
TSVQNRLLKL
650
EESYELIEKN
660
LQLLGATAIE
670
DKLQDQVPET
680
IETLMKADIK
690
IWILTGDKQE
700
TAINIGHSCK
710
LLKKNMGMIV
720
INEGSLDGTR
730
ETLSRHCTTL
740
GDALRKENDF
750
ALIIDGKTLK
760
YALTFGVRQY
770
FLDLALSCKA
780
VICCRVSPLQ
790
KSEVVEMVKK
800
QVKVVTLAIG
810
DGANDVSMIQ
820
TAHVGVGISG
830
NEGLQAANSS
840
DYSIAQFKYL
850
KNLLMIHGAW
860
NYNRVSKCIL
870
YCFYKNIVLY
880
IIEIWFAFVN
890
GFSGQILFER
900
WCIGLYNVMF
910
TAMPPLTLGI
920
FERSCRKENM
930
LKYPELYKTS
940
QNALDFNTKV
950
FWVHCLNGLF
960
HSVILFWFPL
970
KALQYGTAFG
980
NGKTSDYLLL
990
GNFVYTFVVI
1000
TVCLKAGLET
1010
SYWTWFSHIA
1020
IWGSIALWVV
1030
FFGIYSSLWP
1040
AIPMAPDMSG
1050
EAAMLFSSGV
1060
FWMGLLFIPV
1070
ASLLLDVVYK
1080
VIKRTAFKTL
1090
VDEVQELEAK
1100
SQDPGAVVLG
1110
KSLTERAQLL
1120
KNVFKKNHVN
1130
LYRSESLQQN
1140
LLHGYAFSQD
1150
ENGIVSQSEV
1160
IRAYDTTKQR
PDEW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035577 | azurophil granule membrane |
| Cellular Component | GO:0042584 | chromaffin granule membrane |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:1990531 | phospholipid-translocating ATPase complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035579 | specific granule membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140326 | ATPase-coupled intramembrane lipid transporter activity |
| Molecular Function | GO:0019829 | ATPase-coupled monoatomic cation transmembrane transporter activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0140346 | phosphatidylserine flippase activity |
| Molecular Function | GO:0090556 | phosphatidylserine floppase activity |
| Biological Process | GO:0140331 | aminophospholipid translocation |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0045332 | phospholipid translocation |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0061092 | positive regulation of phospholipid translocation |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
Reference
PMID: N/A