Search Results
Overview
| Uniprot ID | Q9Y2Q3 |
|---|---|
| Protein Name | Glutathione S-transferase kappa 1 |
| Gene Name | GSTK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | EHPEMLEKASRELWM |
| 163 | LEKIATPKVKNQLKE |
| 169 | PKVKNQLKETTEAAC |
| 49 | SLITGIMKDSGNKPP |
| 54 | IMKDSGNKPPGLLPR |
| 62 | PPGLLPRKGLYMAND |
| 71 | LYMANDLKLLRHHLQ |
Function
Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds (PubMed:14709161, PubMed:14742434). Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB) (PubMed:14709161)
Protein Sequence
10
MGPLPRTVEL
20
FYDVLSPYSW
30
LGFEILCRYQ
40
NIWNINLQLR
50
PSLITGIMKD
60
SGNKPPGLLP
70
RKGLYMANDL
80
KLLRHHLQIP
90
IHFPKDFLSV
100
MLEKGSLSAM
110
RFLTAVNLEH
120
PEMLEKASRE
130
LWMRVWSRNE
140
DITEPQSILA
150
AAEKAGMSAE
160
QAQGLLEKIA
170
TPKVKNQLKE
180
TTEAACRYGA
190
FGLPITVAHV
200
DGQTHMLFGS
210
DRMELLAHLL
220
GEKWMGPIPP
AVNARL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0046685 | response to arsenic-containing substance |
| Biological Process | GO:0010042 | response to manganese ion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.