Search Results

Overview

Uniprot ID	Q9Y2R4
Protein Name	Probable ATP-dependent RNA helicase DDX52
Gene Name	DDX52
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
126	KKVQRESKLTSGKLE
131	ESKLTSGKLENLRKE
547	EYIKGFQKLLSKQKK

Function

Required for efficient ribosome biogenesis (By similarity). May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity)

Protein Sequence

10 MDVHDLFRRL 20 GAGAKFDTRR 30 FSADAARFQI 40 GKRKYDFDSS 50 EVLQGLDFFG 60 NKKSVPGVCG 70 ASQTHQKPQN 80 GEKKEESLTE 90 RKREQSKKKR 100 KTMTSEIASQ 110 EEGATIQWMS 120 SVEAKIEDKK 130 VQRESKLTSG 140 KLENLRKEKI 150 NFLRNKHKIH 160 VQGTDLPDPI 170 ATFQQLDQEY 180 KINSRLLQNI 190 LDAGFQMPTP 200 IQMQAIPVML 210 HGRELLASAP 220 TGSGKTLAFS 230 IPILMQLKQP 240 ANKGFRALII 250 SPTRELASQI 260 HRELIKISEG 270 TGFRIHMIHK 280 AAVAAKKFGP 290 KSSKKFDILV 300 TTPNRLIYLL 310 KQDPPGIDLA 320 SVEWLVVDES 330 DKLFEDGKTG 340 FRDQLASIFL 350 ACTSHKVRRA 360 MFSATFAYDV 370 EQWCKLNLDN 380 VISVSIGARN 390 SAVETVEQEL 400 LFVGSETGKL 410 LAVRELVKKG 420 FNPPVLVFVQ 430 SIERAKELFH 440 ELIYEGINVD 450 VIHAERTQQQ 460 RDNTVHSFRA 470 GKIWVLICTA 480 LLARGIDFKG 490 VNLVINYDFP 500 TSSVEYIHRI 510 GRTGRAGNKG 520 KAITFFTEDD 530 KPLLRSVANV 540 IQQAGCPVPE 550 YIKGFQKLLS 560 KQKKKMIKKP 570 LERESISTTP 580 KCFLEKAKDK 590 QKKVTGQNSK KKVALEDKS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003724	RNA helicase activity
Biological Process	GO:0030490	maturation of SSU-rRNA

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.