Search Results
Overview
| Uniprot ID | Q9Y2S2 |
|---|---|
| Protein Name | Lambda-crystallin homolog |
| Gene Name | CRYL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | EDLELKKKIFAQLDS |
| 130 | TSCLMPSKLFAGLVH |
| 178 | RTHALMKKIGQCPMR |
| 188 | QCPMRVQKEVAGFVL |
| 279 | FSRATAEKVNQDMCM |
Function
Catalyzes the conversion of L-gulonate to 3-dehydro-L-gulonate (PubMed:15809331, PubMed:40737316). It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate (PubMed:15809331). Utilizes NAD as the sole cosubstrate and shows no activity with NADP (PubMed:40737316)
Protein Sequence
10
MASSAAGCVV
20
IVGSGVIGRS
30
WAMLFASGGF
40
QVKLYDIEQQ
50
QIRNALENIR
60
KEMKLLEQAG
70
SLKGSLSVEE
80
QLSLISGCPN
90
IQEAVEGAMH
100
IQECVPEDLE
110
LKKKIFAQLD
120
SIIDDRVILS
130
SSTSCLMPSK
140
LFAGLVHVKQ
150
CIVAHPVNPP
160
YYIPLVELVP
170
HPETAPTTVD
180
RTHALMKKIG
190
QCPMRVQKEV
200
AGFVLNRLQY
210
AIISEAWRLV
220
EEGIVSPSDL
230
DLVMSEGLGM
240
RYAFIGPLET
250
MHLNAEGMLS
260
YCDRYSEGIK
270
HVLQTFGPIP
280
EFSRATAEKV
290
NQDMCMKVPD
300
DPEHLAARRQ
310
WRDECLMRLA
KLKSQVQPQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0050104 | L-gulonate 3-dehydrogenase activity |
| Molecular Function | GO:0070403 | NAD+ binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0019640 | D-glucuronate catabolic process to D-xylulose 5-phosphate |
| Biological Process | GO:0006631 | fatty acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.