Search Results
Overview
| Uniprot ID | Q9Y2T3 |
|---|---|
| Protein Name | Guanine deaminase |
| Gene Name | GDA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | ETTEESIKETERFVS |
| 259 | KNLYPSYKNYTSVYD |
| 267 | NYTSVYDKNNLLTNK |
| 361 | LINKVNEKSLTLKEV |
| 366 | NEKSLTLKEVFRLAT |
Function
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
Protein Sequence
10
MCAAQMPPLA
20
HIFRGTFVHS
30
TWTCPMEVLR
40
DHLLGVSDSG
50
KIVFLEEASQ
60
QEKLAKEWCF
70
KPCEIRELSH
80
HEFFMPGLVD
90
THIHASQYSF
100
AGSSIDLPLL
110
EWLTKYTFPA
120
EHRFQNIDFA
130
EEVYTRVVRR
140
TLKNGTTTAC
150
YFATIHTDSS
160
LLLADITDKF
170
GQRAFVGKVC
180
MDLNDTFPEY
190
KETTEESIKE
200
TERFVSEMLQ
210
KNYSRVKPIV
220
TPRFSLSCSE
230
TLMGELGNIA
240
KTRDLHIQSH
250
ISENRDEVEA
260
VKNLYPSYKN
270
YTSVYDKNNL
280
LTNKTVMAHG
290
CYLSAEELNV
300
FHERGASIAH
310
CPNSNLSLSS
320
GFLNVLEVLK
330
HEVKIGLGTD
340
VAGGYSYSML
350
DAIRRAVMVS
360
NILLINKVNE
370
KSLTLKEVFR
380
LATLGGSQAL
390
GLDGEIGNFE
400
VGKEFDAILI
410
NPKASDSPID
420
LFYGDFFGDI
430
SEAVIQKFLY
440
LGDDRNIEEV
450
YVGGKQVVPF
SSSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008892 | guanine deaminase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006161 | deoxyguanosine catabolic process |
| Biological Process | GO:0046055 | dGMP catabolic process |
| Biological Process | GO:0046038 | GMP catabolic process |
| Biological Process | GO:0006147 | guanine catabolic process |
| Biological Process | GO:0046098 | guanine metabolic process |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.