Search Results
Overview
| Uniprot ID | Q9Y2U5 |
|---|---|
| Protein Name | Mitogen-activated protein kinase kinase kinase 2 |
| Gene Name | MAP3K2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 71 | KLEDLRSKAKIAFGQ |
Function
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics
Protein Sequence
10
MDDQQALNSI
20
MQDLAVLHKA
30
SRPALSLQET
40
RKAKSSSPKK
50
QNDVRVKFEH
60
RGEKRILQFP
70
RPVKLEDLRS
80
KAKIAFGQSM
90
DLHYTNNELV
100
IPLTTQDDLD
110
KAVELLDRSI
120
HMKSLKILLV
130
INGSTQATNL
140
EPLPSLEDLD
150
NTVFGAERKK
160
RLSIIGPTSR
170
DRSSPPPGYI
180
PDELHQVARN
190
GSFTSINSEG
200
EFIPESMDQM
210
LDPLSLSSPE
220
NSGSGSCPSL
230
DSPLDGESYP
240
KSRMPRAQSY
250
PDNHQEFSDY
260
DNPIFEKFGK
270
GGTYPRRYHV
280
SYHHQEYNDG
290
RKTFPRARRT
300
QGTSLRSPVS
310
FSPTDHSLST
320
SSGSSIFTPE
330
YDDSRIRRRG
340
SDIDNPTLTV
350
MDISPPSRSP
360
RAPTNWRLGK
370
LLGQGAFGRV
380
YLCYDVDTGR
390
ELAVKQVQFD
400
PDSPETSKEV
410
NALECEIQLL
420
KNLLHERIVQ
430
YYGCLRDPQE
440
KTLSIFMEYM
450
PGGSIKDQLK
460
AYGALTENVT
470
RKYTRQILEG
480
VHYLHSNMIV
490
HRDIKGANIL
500
RDSTGNVKLG
510
DFGASKRLQT
520
ICLSGTGMKS
530
VTGTPYWMSP
540
EVISGEGYGR
550
KADIWSVACT
560
VVEMLTEKPP
570
WAEFEAMAAI
580
FKIATQPTNP
590
KLPPHVSDYT
600
RDFLKRIFVE
610
AKLRPSADEL
LRHMFVHYH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004709 | MAP kinase kinase kinase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0000165 | MAPK cascade |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.