Search Results

Overview

Uniprot IDQ9Y2U8
Protein NameInner nuclear membrane protein Man1
Gene NameLEMD3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
171 SLQYRGLKAPPAPLA
300 PLPPLTAKSAGGRLE
42 TRPVYLKKLKKLREE
438 GSNHTYLKNTYNKPK
45 VYLKKLKKLREEEQQ

Function

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest

Protein Sequence

10 MAAAAASAPQ 20 QLSDEELFSQ 30 LRRYGLSPGP 40 VTESTRPVYL 50 KKLKKLREEE 60 QQQHRSGGRG 70 NKTRNSNNNN 80 TAAATVAAAG 90 PAAAAAAGMG 100 VRPVSGDLSY 110 LRTPGGLCRI 120 SASGPESLLG 130 GPGGASAAPA 140 AGSKVLLGFS 150 SDESDVEASP 160 RDQAGGGGRK 170 DRASLQYRGL 180 KAPPAPLAAS 190 EVTNSNSAER 200 RKPHSWWGAR 210 RPAGPELQTP 220 PGKDGAVEDE 230 EGEGEDGEER 240 DPETEEPLWA 250 SRTVNGSRLV 260 PYSCRENYSD 270 SEEEDDDDVA 280 SSRQVLKDDS 290 LSRHRPRRTH 300 SKPLPPLTAK 310 SAGGRLETSV 320 QGGGGLAMND 330 RAAAAGSLDR 340 SRNLEEAAAA 350 EQGGGCDQVD 360 SSPVPRYRVN 370 AKKLTPLLPP 380 PLTDMDSTLD 390 SSTGSLLKTN 400 NHIGGGAFSV 410 DSPRIYSNSL 420 PPSAAVAASS 430 SLRINHANHT 440 GSNHTYLKNT 450 YNKPKLSEPE 460 EELLQQFKRE 470 EVSPTGSFSA 480 HYLSMFLLTA 490 ACLFFLILGL 500 TYLGMRGTGV 510 SEDGELSIEN 520 PFGETFGKIQ 530 ESEKTLMMNT 540 LYKLHDRLAQ 550 LAGDHECGSS 560 SQRTLSVQEA 570 AAYLKDLGPE 580 YEGIFNTSLQ 590 WILENGKDVG 600 IRCVGFGPEE 610 ELTNITDVQF 620 LQSTRPLMSF 630 WCRFRRAFVT 640 VTHRLLLLCL 650 GVVMVCVVLR 660 YMKYRWTKEE 670 EETRQMYDMV 680 VKIIDVLRSH 690 NEACQENKDL 700 QPYMPIPHVR 710 DSLIQPHDRK 720 KMKKVWDRAV 730 DFLAANESRV 740 RTETRRIGGA 750 DFLVWRWIQP 760 SASCDKILVI 770 PSKVWQGQAF 780 HLDRRNSPPN 790 SLTPCLKIRN 800 MFDPVMEIGD 810 QWHLAIQEAI 820 LEKCSDNDGI 830 VHIAVDKNSR 840 EGCVYVKCLS 850 PEYAGKAFKA 860 LHGSWFDGKL 870 VTVKYLRLDR 880 YHHRFPQALT 890 SNTPLKPSNK 900 HMNSMSHLRL 910 RTGLTNSQGS S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005637 nuclear inner membrane
Cellular Component GO:0031965 nuclear membrane
Molecular Function GO:0003677 DNA binding
Molecular Function GO:1990446 U1 snRNP binding
Biological Process GO:0032926 negative regulation of activin receptor signaling pathway
Biological Process GO:0030514 negative regulation of BMP signaling pathway
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.