Search Results
Overview
| Uniprot ID | Q9Y2V2 |
|---|---|
| Protein Name | Calcium-regulated heat-stable protein 1 |
| Gene Name | CARHSP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 64 | ASQGPVYKGVCKCFC |
| 74 | CKCFCRSKGHGFITP |
Function
Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro)
Protein Sequence
10
MSSEPPPPPQ
20
PPTHQASVGL
30
LDTPRSRERS
40
PSPLRGNVVP
50
SPLPTRRTRT
60
FSATVRASQG
70
PVYKGVCKCF
80
CRSKGHGFIT
90
PADGGPDIFL
100
HISDVEGEYV
110
PVEGDEVTYK
120
MCSIPPKNEK
130
LQAVEVVITH
140
LAPGTKHETW
SGHVISS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000177 | cytoplasmic exosome (RNase complex) |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043186 | P granule |
| Cellular Component | GO:0000932 | P-body |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0019902 | phosphatase binding |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0043488 | regulation of mRNA stability |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.