Search Results

Overview

Uniprot IDQ9Y2W2
Protein NameWW domain-binding protein 11
Gene NameWBP11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 TSSTKSGKFMNPTDQ
218 VVQMYGRKVGFALDL
316 RFADMPGKSRKKKKN
46 MVRAAVLKMKDPKQI
545 PNLIQRPKADDTSAA
556 TSAATIEKKATATIS
557 SAATIEKKATATISA
565 ATATISAKPQITNPK
572 KPQITNPKAEITRFV
590 LRVRRENKGATAAPQ
599 ATAAPQRKSEDDSAV
610 DSAVPLAKAAPKSGP
614 PLAKAAPKSGPSVPV

Function

Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity

Protein Sequence

10 MGRRSTSSTK 20 SGKFMNPTDQ 30 ARKEARKREL 40 KKNKKQRMMV 50 RAAVLKMKDP 60 KQIIRDMEKL 70 DEMEFNPVQQ 80 PQLNEKVLKD 90 KRKKLRETFE 100 RILRLYEKEN 110 PDIYKELRKL 120 EVEYEQKRAQ 130 LSQYFDAVKN 140 AQHVEVESIP 150 LPDMPHAPSN 160 ILIQDIPLPG 170 AQPPSILKKT 180 SAYGPPTRAV 190 SILPLLGHGV 200 PRLPPGRKPP 210 GPPPGPPPPQ 220 VVQMYGRKVG 230 FALDLPPRRR 240 DEDMLYSPEL 250 AQRGHDDDVS 260 STSEDDGYPE 270 DMDQDKHDDS 280 TDDSDTDKSD 290 GESDGDEFVH 300 RDNGERDNNE 310 EKKSGLSVRF 320 ADMPGKSRKK 330 KKNMKELTPL 340 QAMMLRMAGQ 350 EIPEEGREVE 360 EFSEDDDEDD 370 SDDSEAEKQS 380 QKQHKEESHS 390 DGTSTASSQQ 400 QAPPQSVPPS 410 QIQAPPMPGP 420 PPLGPPPAPP 430 LRPPGPPTGL 440 PPGPPPGAPP 450 FLRPPGMPGL 460 RGPLPRLLPP 470 GPPPGRPPGP 480 PPGPPPGLPP 490 GPPPRGPPPR 500 LPPPAPPGIP 510 PPRPGMMRPP 520 LVPPLGPAPP 530 GLFPPAPLPN 540 PGVLSAPPNL 550 IQRPKADDTS 560 AATIEKKATA 570 TISAKPQITN 580 PKAEITRFVP 590 TALRVRRENK 600 GATAAPQRKS 610 EDDSAVPLAK 620 AAPKSGPSVP 630 VSVQTKDDVY 640 EAFMKEMEGL L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0019888 protein phosphatase regulator activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003697 single-stranded DNA binding
Molecular Function GO:0050699 WW domain binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing
Biological Process GO:0006364 rRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.