Search Results

Overview

Uniprot ID	Q9Y2W6
Protein Name	Tudor and KH domain-containing protein
Gene Name	TDRKH
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
162	GAKITCDKESEGTLL

Function

Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules

Protein Sequence

10 MSTERTSWTS 20 LSTIQKIALG 30 LGIPASATVA 40 YILYRRYRES 50 REERLTFVGE 60 DDIEIEMRVP 70 QEAVKLIIGR 80 QGANIKQLRK 90 QTGARIDVDT 100 EDVGDERVLL 110 ISGFPVQVCK 120 AKAAIHQILT 130 ENTPVSEQLS 140 VPQRSVGRII 150 GRGGETIRSI 160 CKASGAKITC 170 DKESEGTLLL 180 SRLIKISGTQ 190 KEVAAAKHLI 200 LEKVSEDEEL 210 RKRIAHSAET 220 RVPRKQPISV 230 RREDMTEPGG 240 AGEPALWKNT 250 SSSMEPTAPL 260 VTPPPKGGGD 270 MAVVVSKEGS 280 WEKPSDDSFQ 290 KSEAQAIPEM 300 PMFEIPSPDF 310 SFHADEYLEV 320 YVSASEHPNH 330 FWIQIVGSRS 340 LQLDKLVNEM 350 TQHYENSVPE 360 DLTVHVGDIV 370 AAPLPTNGSW 380 YRARVLGTLE 390 NGNLDLYFVD 400 FGDNGDCPLK 410 DLRALRSDFL 420 SLPFQAIECS 430 LARIAPSGDQ 440 WEEEALDEFD 450 RLTHCADWKP 460 LVAKISSYVQ 470 TGISTWPKIY 480 LYDTSNGKKL 490 DIGLELVHKG 500 YAIELPEDIE 510 ENRAVPDMLK 520 DMATETDASL 530 STLLTETKKS 540 SGEITHTLSC 550 LSLSEAASMS 560 GDDNLEDDYL L

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Biological Process	GO:0007283	spermatogenesis
Cellular Component	GO:0043186	P granule
Cellular Component	GO:0071546	pi-body
Cellular Component	GO:0071547	piP-body
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0009566	fertilization
Biological Process	GO:0007140	male meiotic nuclear division
Biological Process	GO:0030719	P granule organization
Biological Process	GO:0034587	piRNA processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.