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Overview

Uniprot IDQ9Y2X0
Protein NameMediator of RNA polymerase II transcription subunit 16
Gene NameMED16
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
420 PVDEPAMKRPRTAGP

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Protein Sequence

10 MCDLRRPAAG 20 GMMDLAYVCE 30 WEKWSKSTHC 40 PSVPLACAWS 50 CRNLIAFTMD 60 LRSDDQDLTR 70 MIHILDTEHP 80 WDLHSIPSEH 90 HEAITCLEWD 100 QSGSRLLSAD 110 ADGQIKCWSM 120 ADHLANSWES 130 SVGSLVEGDP 140 IVALSWLHNG 150 VKLALHVEKS 160 GASSFGEKFS 170 RVKFSPSLTL 180 FGGKPMEGWI 190 AVTVSGLVTV 200 SLLKPSGQVL 210 TSTESLCRLR 220 GRVALADIAF 230 TGGGNIVVAT 240 ADGSSASPVQ 250 FYKVCVSVVS 260 EKCRIDTEIL 270 PSLFMRCTTD 280 LNRKDKFPAI 290 THLKFLARDM 300 SEQVLLCASS 310 QTSSIVECWS 320 LRKEGLPVNN 330 IFQQISPVVG 340 DKQPTILKWR 350 ILSATNDLDR 360 VSAVALPKLP 370 ISLTNTDLKV 380 ASDTQFYPGL 390 GLALAFHDGS 400 VHIVHRLSLQ 410 TMAVFYSSAA 420 PRPVDEPAMK 430 RPRTAGPAVH 440 LKAMQLSWTS 450 LALVGIDSHG 460 KLSVLRLSPS 470 MGHPLEVGLA 480 LRHLLFLLEY 490 CMVTGYDWWD 500 ILLHVQPSMV 510 QSLVEKLHEE 520 YTRQTAALQQ 530 VLSTRILAMK 540 ASLCKLSPCT 550 VTRVCDYHTK 560 LFLIAISSTL 570 KSLLRPHFLN 580 TPDKSPGDRL 590 TEICTKITDV 600 DIDKVMINLK 610 TEEFVLDMNT 620 LQALQQLLQW 630 VGDFVLYLLA 640 SLPNQGSLLR 650 PGHSFLRDGT 660 SLGMLRELMV 670 VIRIWGLLKP 680 SCLPVYTATS 690 DTQDSMSLLF 700 RLLTKLWICC 710 RDEGPASEPD 720 EALVDECCLL 730 PSQLLIPSLD 740 WLPASDGLVS 750 RLQPKQPLRL 760 QFGRAPTLPG 770 SAATLQLDGL 780 ARAPGQPKID 790 HLRRLHLGAC 800 PTEECKACTR 810 CGCVTMLKSP 820 NRTTAVKQWE 830 QRWIKNCLAV 840 EGRGPDACVT 850 SRASEEAPAF 860 VQLGPQSTHH 870 SPRTPRSLDH LHPEDRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0042809 nuclear vitamin D receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0051123 RNA polymerase II preinitiation complex assembly
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

PMID: N/A