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Overview

Uniprot IDQ9Y2X9
Protein NameZinc finger protein 281
Gene NameZNF281
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
220 KQDTNVKKAKRPKPE
409 SRRKTKSKSIAIENK
464 ELQKRVPKLIFKKGS
473 IFKKGSRKNTDKNYL
539 DDAMQFSKKRRYLPT
540 DAMQFSKKRRYLPTA
787 AFQSSSQKLTSQKEQ

Function

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes

Protein Sequence

10 MKIGSGFLSG 20 GGGTGSSGGS 30 GSGGGGSGGG 40 GGGGSSGRRA 50 EMEPTFPQGM 60 VMFNHRLPPV 70 TSFTRPAGSA 80 APPPQCVLSS 90 STSAAPAAEP 100 PPPPAPDMTF 110 KKEPAASAAA 120 FPSQRTSWGF 130 LQSLVSIKQE 140 KPADPEEQQS 150 HHHHHHHHYG 160 GLFAGAEERS 170 PGLGGGEGGS 180 HGVIQDLSIL 190 HQHVQQQPAQ 200 HHRDVLLSSS 210 SRTDDHHGTE 220 EPKQDTNVKK 230 AKRPKPESQG 240 IKAKRKPSAS 250 SKPSLVGDGE 260 GAILSPSQKP 270 HICDHCSAAF 280 RSSYHLRRHV 290 LIHTGERPFQ 300 CSQCSMGFIQ 310 KYLLQRHEKI 320 HSREKPFGCD 330 QCSMKFIQKY 340 HMERHKRTHS 350 GEKPYKCDTC 360 QQYFSRTDRL 370 LKHRRTCGEV 380 IVKGATSAEP 390 GSSNHTNMGN 400 LAVLSQGNTS 410 SSRRKTKSKS 420 IAIENKEQKT 430 GKTNESQISN 440 NINMQSYSVE 450 MPTVSSSGGI 460 IGTGIDELQK 470 RVPKLIFKKG 480 SRKNTDKNYL 490 NFVSPLPDIV 500 GQKSLSGKPS 510 GSLGIVSNNS 520 VETIGLLQST 530 SGKQGQISSN 540 YDDAMQFSKK 550 RRYLPTASSN 560 SAFSINVGHM 570 VSQQSVIQSA 580 GVSVLDNEAP 590 LSLIDSSALN 600 AEIKSCHDKS 610 GIPDEVLQSI 620 LDQYSNKSES 630 QKEDPFNIAE 640 PRVDLHTSGE 650 HSELVQEENL 660 SPGTQTPSND 670 KASMLQEYSK 680 YLQQAFEKST 690 NASFTLGHGF 700 QFVSLSSPLH 710 NHTLFPEKQI 720 YTTSPLECGF 730 GQSVTSVLPS 740 SLPKPPFGML 750 FGSQPGLYLS 760 ALDATHQQLT 770 PSQELDDLID 780 SQKNLETSSA 790 FQSSSQKLTS 800 QKEQKNLESS 810 TGFQIPSQEL 820 ASQIDPQKDI 830 EPRTTYQIEN 840 FAQAFGSQFK 850 SGSRVPMTFI 860 TNSNGEVDHR 870 VRTSVSDFSG 880 YTNMMSDVSE 890 PCSTRVKTPT SQSYR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0010172 embryonic body morphogenesis
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0048863 stem cell differentiation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.