Search Results
Overview
| Uniprot ID | Q9Y2Z4 |
|---|---|
| Protein Name | Tyrosine--tRNA ligase, mitochondrial |
| Gene Name | YARS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 355 | RLAAEVTKLVHGREG |
| 49 | QKARGLFKDFFPETG |
Function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)
Protein Sequence
10
MAAPILRSFS
20
WGRWSGTLNL
30
SVLLPLGLRK
40
AHSGAQGLLA
50
AQKARGLFKD
60
FFPETGTKIE
70
LPELFDRGTA
80
SFPQTIYCGF
90
DPTADSLHVG
100
HLLALLGLFH
110
LQRAGHNVIA
120
LVGGATARLG
130
DPSGRTKERE
140
ALETERVRAN
150
ARALRLGLEA
160
LAANHQQLFT
170
DGRSWGSFTV
180
LDNSAWYQKQ
190
HLVDFLAAVG
200
GHFRMGTLLS
210
RQSVQLRLKS
220
PEGMSLAEFF
230
YQVLQAYDFY
240
YLFQRYGCRV
250
QLGGSDQLGN
260
IMSGYEFINK
270
LTGEDVFGIT
280
VPLITSTTGA
290
KLGKSAGNAV
300
WLNRDKTSPF
310
ELYQFFVRQP
320
DDSVERYLKL
330
FTFLPLPEID
340
HIMQLHVKEP
350
ERRGPQKRLA
360
AEVTKLVHGR
370
EGLDSAKRCT
380
QALYHSSIDA
390
LEVMSDQELK
400
ELFKEAPFSE
410
FFLDPGTSVL
420
DTCRKANAIP
430
DGPRGYRMIT
440
EGGVSINHQQ
450
VTNPESVLIV
460
GQHILKNGLS
470
LLKIGKRNFY
IIKWLQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0072545 | L-tyrosine binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0004831 | tyrosine-tRNA ligase activity |
| Biological Process | GO:0070184 | mitochondrial tyrosyl-tRNA aminoacylation |
| Biological Process | GO:0006412 | translation |
| Biological Process | GO:0043039 | tRNA aminoacylation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.