Search Results

Overview

Uniprot ID	Q9Y305
Protein Name	Acyl-coenzyme A thioesterase 9, mitochondrial
Gene Name	ACOT9
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
103	SEPELREKYLTVQNT
157	DKIDMCKKSLSPEQD
292	AVWMENSKLKSLEIC
294	WMENSKLKSLEICHP
31	QGPQNPKKQGIFHIH

Function

Mitochondrial acyl-CoA thioesterase. Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoA), regulating their respective intracellular levels. Regulates both mitochondrial lipid and amino acid metabolism

Protein Sequence

10 MRRAALRLCA 20 LGKGQLTPGR 30 GLTQGPQNPK 40 KQGIFHIHEV 50 RDKLREIVGA 60 STNWRDHVKA 70 MEERKLLHSF 80 LAKSQDGLPP 90 RRMKDSYIEV 100 LLPLGSEPEL 110 REKYLTVQNT 120 VRFGRILEDL 130 DSLGVLICYM 140 HNKIHSAKMS 150 PLSIVTALVD 160 KIDMCKKSLS 170 PEQDIKFSGH 180 VSWVGKTSME 190 VKMQMFQLHG 200 DEFCPVLDAT 210 FVMVARDSEN 220 KGPAFVNPLI 230 PESPEEEELF 240 RQGELNKGRR 250 IAFSSTSLLK 260 MAPSAEERTT 270 IHEMFLSTLD 280 PKTISFRSRV 290 LPSNAVWMEN 300 SKLKSLEICH 310 PQERNIFNRI 320 FGGFLMRKAY 330 ELAWATACSF 340 GGSRPFVVAV 350 DDIMFQKPVE 360 VGSLLFLSSQ 370 VCFTQNNYIQ 380 VRVHSEVASL 390 QEKQHTTTNV 400 FHFTFMSEKE 410 VPLVFPKTYG 420 ESMLYLDGQR 430 HFNSMSGPAT LRKDYLVEP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0003986	acetyl-CoA hydrolase activity
Molecular Function	GO:0052689	carboxylic ester hydrolase activity
Molecular Function	GO:0047617	fatty acyl-CoA hydrolase activity
Molecular Function	GO:0052816	long-chain fatty acyl-CoA hydrolase activity
Biological Process	GO:0006637	acyl-CoA metabolic process
Biological Process	GO:0001676	long-chain fatty acid metabolic process
Biological Process	GO:0046459	short-chain fatty acid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.