Search Results

Overview

Uniprot IDQ9Y365
Protein NameSTART domain-containing protein 10
Gene NameSTARD10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
197 DPKGSLPKWVVNKSS

Function

May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes

Protein Sequence

10 MEKLAASTEP 20 QGPRPVLGRE 30 SVQVPDDQDF 40 RSFRSECEAE 50 VGWNLTYSRA 60 GVSVWVQAVE 70 MDRTLHKIKC 80 RMECCDVPAE 90 TLYDVLHDIE 100 YRKKWDSNVI 110 ETFDIARLTV 120 NADVGYYSWR 130 CPKPLKNRDV 140 ITLRSWLPMG 150 ADYIIMNYSV 160 KHPKYPPRKD 170 LVRAVSIQTG 180 YLIQSTGPKS 190 CVITYLAQVD 200 PKGSLPKWVV 210 NKSSQFLAPK 220 AMKKMYKACL 230 KYPEWKQKHL 240 PHFKPWLHPE 250 QSPLPSLALS 260 ELSVQHADSL 270 ENIDESAVAE 280 SREERMGGAG 290 GEGSDDDTSL T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0046581 intercellular canaliculus
Cellular Component GO:0016020 membrane
Cellular Component GO:0005902 microvillus
Cellular Component GO:0031514 motile cilium
Molecular Function GO:0005319 lipid transporter activity
Molecular Function GO:0031210 phosphatidylcholine binding
Biological Process GO:0006656 phosphatidylcholine biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.