Overview
| Uniprot ID | Q9Y371 |
|---|
| Protein Name | Endophilin-B1 |
|---|
| Gene Name | SH3GLB1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 10 |
IMDFNVKKLAADAGT |
Function
May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity)
Protein Sequence
10
MNIMDFNVKK
20
LAADAGTFLS
30
RAVQFTEEKL
40
GQAEKTELDA
50
HLENLLSKAE
60
CTKIWTEKIM
70
KQTEVLLQPN
80
PNARIEEFVY
90
EKLDRKAPSR
100
INNPELLGQY
110
MIDAGTEFGP
120
GTAYGNALIK
130
CGETQKRIGT
140
ADRELIQTSA
150
LNFLTPLRNF
160
IEGDYKTIAK
170
ERKLLQNKRL
180
DLDAAKTRLK
190
KAKAAETRNS
200
SEQELRITQS
210
EFDRQAEITR
220
LLLEGISSTH
230
AHHLRCLNDF
240
VEAQMTYYAQ
250
CYQYMLDLQK
260
QLGSFPSNYL
270
SNNNQTSVTP
280
VPSVLPNAIG
290
SSAMASTSGL
300
VITSPSNLSD
310
LKECSGSRKA
320
RVLYDYDAAN
330
STELSLLADE
340
VITVFSVVGM
350
DSDWLMGERG
360
NQKGKVPITY
LELLN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000421 |
autophagosome membrane |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0005504 |
fatty acid binding |
| Molecular Function |
GO:0042171 |
lysophosphatidic acid acyltransferase activity |
| Molecular Function |
GO:0141038 |
phosphatidylinositol 3-kinase activator activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0048102 |
autophagic cell death |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0034198 |
cellular response to amino acid starvation |
| Biological Process |
GO:0042149 |
cellular response to glucose starvation |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0090148 |
membrane fission |
| Biological Process |
GO:0061024 |
membrane organization |
| Biological Process |
GO:2000786 |
positive regulation of autophagosome assembly |
| Biological Process |
GO:0010508 |
positive regulation of autophagy |
| Biological Process |
GO:1903527 |
positive regulation of membrane tubulation |
| Biological Process |
GO:1903955 |
positive regulation of protein targeting to mitochondrion |
| Biological Process |
GO:0031334 |
positive regulation of protein-containing complex assembly |
| Biological Process |
GO:1903778 |
protein localization to vacuolar membrane |
| Biological Process |
GO:0032801 |
receptor catabolic process |
| Biological Process |
GO:0032465 |
regulation of cytokinesis |
| Biological Process |
GO:0016241 |
regulation of macroautophagy |
| Biological Process |
GO:0031647 |
regulation of protein stability |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.