Search Results

Overview

Uniprot IDQ9Y376
Protein NameCalcium-binding protein 39
Gene NameCAB39
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 FPFGKSHKSPADIVK
196 KDLLTRHKLLSAEFL
226 HSENYVTKRQSLKLL
7 *MPFPFGKSHKSPAD

Function

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Protein Sequence

10 MPFPFGKSHK 20 SPADIVKNLK 30 ESMAVLEKQD 40 ISDKKAEKAT 50 EEVSKNLVAM 60 KEILYGTNEK 70 EPQTEAVAQL 80 AQELYNSGLL 90 STLVADLQLI 100 DFEGKKDVAQ 110 IFNNILRRQI 120 GTRTPTVEYI 130 CTQQNILFML 140 LKGYESPEIA 150 LNCGIMLREC 160 IRHEPLAKII 170 LWSEQFYDFF 180 RYVEMSTFDI 190 ASDAFATFKD 200 LLTRHKLLSA 210 EFLEQHYDRF 220 FSEYEKLLHS 230 ENYVTKRQSL 240 KLLGELLLDR 250 HNFTIMTKYI 260 SKPENLKLMM 270 NLLRDKSRNI 280 QFEAFHVFKV 290 FVANPNKTQP 300 ILDILLKNQA 310 KLIEFLSKFQ 320 NDRTEDEQFN 330 DEKTYLVKQI 340 RDLKRPAQQE A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:1902554 serine/threonine protein kinase complex
Cellular Component GO:0030018 Z disc
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0030295 protein kinase activator activity
Molecular Function GO:0043539 protein serine/threonine kinase activator activity
Molecular Function GO:0120283 protein serine/threonine kinase binding
Biological Process GO:0071476 cellular hypotonic response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:1901380 negative regulation of potassium ion transmembrane transport
Biological Process GO:0014823 response to activity
Biological Process GO:0097066 response to thyroid hormone
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.