Overview
| Uniprot ID | Q9Y394 |
|---|
| Protein Name | Dehydrogenase/reductase SDR family member 7 |
|---|
| Gene Name | DHRS7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 101 |
CLENGNLKEKDILVL |
| 171 |
LGTVSLTKCVLPHMI |
| 321 |
KKRIENFKSGVDADS |
Function
NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28457967, PubMed:28687384). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046)
Protein Sequence
10
MNWELLLWLL
20
VLCALLLLLV
30
QLLRFLRADG
40
DLTLLWAEWQ
50
GRRPEWELTD
60
MVVWVTGASS
70
GIGEELAYQL
80
SKLGVSLVLS
90
ARRVHELERV
100
KRRCLENGNL
110
KEKDILVLPL
120
DLTDTGSHEA
130
ATKAVLQEFG
140
RIDILVNNGG
150
MSQRSLCMDT
160
SLDVYRKLIE
170
LNYLGTVSLT
180
KCVLPHMIER
190
KQGKIVTVNS
200
ILGIISVPLS
210
IGYCASKHAL
220
RGFFNGLRTE
230
LATYPGIIVS
240
NICPGPVQSN
250
IVENSLAGEV
260
TKTIGNNGDQ
270
SHKMTTSRCV
280
RLMLISMAND
290
LKEVWISEQP
300
FLLVTYLWQY
310
MPTWAWWITN
320
KMGKKRIENF
330
KSGVDADSSY
FKIFKTKHD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0052650 |
all-trans-retinol dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0004090 |
carbonyl reductase (NADPH) activity |
| Molecular Function |
GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.