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Overview

Uniprot ID	Q9Y3A4
Protein Name	Ribosomal RNA-processing protein 7 homolog A
Gene Name	RRP7A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
250	AWQHRESKMEHLAQL

Function

Nucleolar protein that is involved in ribosomal RNA (rRNA) processing (PubMed:33199730). Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development (PubMed:33199730). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Protein Sequence

10 MVARRRKCAA 20 RDPEDRIPSP 30 LGYAAIPIKF 40 SEKQQASHYL 50 YVRAHGVRQG 60 TKSTWPQKRT 70 LFVLNVPPYC 80 TEESLSRLLS 90 TCGLVQSVEL 100 QEKPDLAESP 110 KESRSKFFHP 120 KPVPGFQVAY 130 VVFQKPSGVS 140 AALALKGPLL 150 VSTESHPVKS 160 GIHKWISDYA 170 DSVPDPEALR 180 VEVDTFMEAY 190 DQKIAEEEAK 200 AKEEEGVPDE 210 EGWVKVTRRG 220 RRPVLPRTEA 230 ASLRVLERER 240 RKRSRKELLN 250 FYAWQHRESK 260 MEHLAQLRKK 270 FEEDKQRIEL 280 LRAQRKFRPY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0032545	CURI complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0032040	small-subunit processome
Cellular Component	GO:0034456	UTP-C complex
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0061523	cilium disassembly
Biological Process	GO:0030490	maturation of SSU-rRNA
Biological Process	GO:1902570	protein localization to nucleolus
Biological Process	GO:0000028	ribosomal small subunit assembly
Biological Process	GO:0042274	ribosomal small subunit biogenesis
Biological Process	GO:0042254	ribosome biogenesis
Biological Process	GO:0006364	rRNA processing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.