Search Results

Overview

Uniprot IDQ9Y3B3
Protein NameTransmembrane emp24 domain-containing protein 7
Gene NameTMED7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
91 VLYKEMKKQYDSFTF

Function

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications

Protein Sequence

10 MPRPGSAQRW 20 AAVAGRWGCR 30 LLALLLLVPG 40 PGGASEITFE 50 LPDNAKQCFY 60 EDIAQGTKCT 70 LEFQVITGGH 80 YDVDCRLEDP 90 DGKVLYKEMK 100 KQYDSFTFTA 110 SKNGTYKFCF 120 SNEFSTFTHK 130 TVYFDFQVGE 140 DPPLFPSENR 150 VSALTQMESA 160 CVSIHEALKS 170 VIDYQTHFRL 180 REAQGRSRAE 190 DLNTRVAYWS 200 VGEALILLVV 210 SIGQVFLLKS 220 FFSDKRTTTT RVGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030133 transport vesicle
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0007030 Golgi organization
Biological Process GO:0006886 intracellular protein transport
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0030127 COPII vesicle coat
Cellular Component GO:0030134 COPII-coated ER to Golgi transport vesicle
Cellular Component GO:0005783 endoplasmic reticulum

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.