Search Results

Overview

Uniprot ID	Q9Y3C8
Protein Name	Ubiquitin-fold modifier-conjugating enzyme 1
Gene Name	UFC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
122	ICLTDHFKPLWARNV
33	ELWVQRLKEEYQSLI

Function

E2-like enzyme which specifically catalyzes the second step in ufmylation (PubMed:15071506, PubMed:29868776, PubMed:30626644, PubMed:34588452, PubMed:35394863, PubMed:36121123, PubMed:38383789). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (PubMed:15071506, PubMed:29868776, PubMed:34588452, PubMed:38383789). Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:27351204, PubMed:32160526, PubMed:35394863, PubMed:37036982, PubMed:38383789)

Protein Sequence

10 MADEATRRVV 20 SEIPVLKTNA 30 GPRDRELWVQ 40 RLKEEYQSLI 50 RYVENNKNAD 60 NDWFRLESNK 70 EGTRWFGKCW 80 YIHDLLKYEF 90 DIEFDIPITY 100 PTTAPEIAVP 110 ELDGKTAKMY 120 RGGKICLTDH 130 FKPLWARNVP 140 KFGLAHLMAL 150 GLGPWLAVEI 160 PDLIQKGVIQ HKEKCNQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0070062	extracellular exosome
Molecular Function	GO:0061657	UFM1 conjugating enzyme activity
Molecular Function	GO:0071568	UFM1 transferase activity
Biological Process	GO:0007420	brain development
Biological Process	GO:1990592	protein K69-linked ufmylation
Biological Process	GO:0071569	protein ufmylation
Biological Process	GO:0032649	regulation of type II interferon production
Biological Process	GO:0034976	response to endoplasmic reticulum stress
Biological Process	GO:0061709	reticulophagy

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.