Search Results
Overview
| Uniprot ID | Q9Y3D2 |
|---|---|
| Protein Name | Methionine-R-sulfoxide reductase B2, mitochondrial |
| Gene Name | MSRB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 57 | AKSEWQKKLTPEQFY |
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0033745 | L-methionine (R)-S-oxide reductase activity |
| Molecular Function | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0030091 | protein repair |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.