Search Results
Overview
| Uniprot ID | Q9Y3D6 |
|---|---|
| Protein Name | Mitochondrial fission 1 protein |
| Gene Name | FIS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | EKKFQSEKAAGSVSK |
| 46 | AWCLVRSKYNDDIRK |
Function
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0071396 | cellular response to lipid |
| Biological Process | GO:1901653 | cellular response to peptide |
| Biological Process | GO:0097237 | cellular response to toxic substance |
| Biological Process | GO:0000266 | mitochondrial fission |
| Biological Process | GO:0043653 | mitochondrial fragmentation involved in apoptotic process |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:1903579 | negative regulation of ATP metabolic process |
| Biological Process | GO:2000192 | negative regulation of fatty acid transport |
| Biological Process | GO:0016559 | peroxisome fission |
| Biological Process | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0090141 | positive regulation of mitochondrial fission |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:0006626 | protein targeting to mitochondrion |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:1905395 | response to flavonoid |
| Biological Process | GO:1902617 | response to fluoride |
| Biological Process | GO:1990910 | response to hypobaric hypoxia |
| Biological Process | GO:0014850 | response to muscle activity |
| Biological Process | GO:0031667 | response to nutrient levels |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.