Search Results
Overview
| Uniprot ID | Q9Y3E5 |
|---|---|
| Protein Name | Peptidyl-tRNA hydrolase 2, mitochondrial |
| Gene Name | PTRH2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | LPKSKTSKTHTDTES |
Function
Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis (PubMed:14660562). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1
Protein Sequence
10
MPSKSLVMEY
20
LAHPSTLGLA
30
VGVACGMCLG
40
WSLRVCFGML
50
PKSKTSKTHT
60
DTESEASILG
70
DSGEYKMILV
80
VRNDLKMGKG
90
KVAAQCSHAA
100
VSAYKQIQRR
110
NPEMLKQWEY
120
CGQPKVVVKA
130
PDEETLIALL
140
AHAKMLGLTV
150
SLIQDAGRTQ
160
IAPGSQTVLG
170
IGPGPADLID
KVTGHLKLY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004045 | peptidyl-tRNA hydrolase activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:2000811 | negative regulation of anoikis |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:2000210 | positive regulation of anoikis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.