Overview
| Uniprot ID | Q9Y3F4 |
|---|
| Protein Name | Serine-threonine kinase receptor-associated protein |
|---|
| Gene Name | STRAP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 156 |
ALWCSEDKQILSADD |
Function
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein
Protein Sequence
10
MAMRQTPLTC
20
SGHTRPVVDL
30
AFSGITPYGY
40
FLISACKDGK
50
PMLRQGDTGD
60
WIGTFLGHKG
70
AVWGATLNKD
80
ATKAATAAAD
90
FTAKVWDAVS
100
GDELMTLAHK
110
HIVKTVDFTQ
120
DSNYLLTGGQ
130
DKLLRIYDLN
140
KPEAEPKEIS
150
GHTSGIKKAL
160
WCSEDKQILS
170
ADDKTVRLWD
180
HATMTEVKSL
190
NFNMSVSSME
200
YIPEGEILVI
210
TYGRSIAFHS
220
AVSLDPIKSF
230
EAPATINSAS
240
LHPEKEFLVA
250
GGEDFKLYKY
260
DYNSGEELES
270
YKGHFGPIHC
280
VRFSPDGELY
290
ASGSEDGTLR
300
LWQTVVGKTY
310
GLWKCVLPEE
320
DSGELAKPKI
330
GFPETTEEEL
340
EEIASENSDC
350
IFPSAPDVKA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032797 |
SMN complex |
| Cellular Component |
GO:0034719 |
SMN-Sm protein complex |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:1990447 |
U2 snRNP binding |
| Biological Process |
GO:0000380 |
alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0030277 |
maintenance of gastrointestinal epithelium |
| Biological Process |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:0000387 |
spliceosomal snRNP assembly |
Reference
PMID: N/A