Search Results

Overview

Uniprot IDQ9Y3T9
Protein NameNucleolar complex protein 2 homolog
Gene NameNOC2L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
144 PRGLKGKKNSVPVTV
649 DLNFPEIKRRKMADR
70 KGRASEHKDQLSRLK
77 KDQLSRLKDRDPEFY

Function

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter

Protein Sequence

10 MAAAGSRKRR 20 LAELTVDEFL 30 ASGFDSESES 40 ESENSPQAET 50 REAREAARSP 60 DKPGGSPSAS 70 RRKGRASEHK 80 DQLSRLKDRD 90 PEFYKFLQEN 100 DQSLLNFSDS 110 DSSEEEEGPF 120 HSLPDVLEEA 130 SEEEDGAEEG 140 EDGDRVPRGL 150 KGKKNSVPVT 160 VAMVERWKQA 170 AKQRLTPKLF 180 HEVVQAFRAA 190 VATTRGDQES 200 AEANKFQVTD 210 SAAFNALVTF 220 CIRDLIGCLQ 230 KLLFGKVAKD 240 SSRMLQPSSS 250 PLWGKLRVDI 260 KAYLGSAIQL 270 VSCLSETTVL 280 AAVLRHISVL 290 VPCFLTFPKQ 300 CRMLLKRMVI 310 VWSTGEESLR 320 VLAFLVLSRV 330 CRHKKDTFLG 340 PVLKQMYITY 350 VRNCKFTSPG 360 ALPFISFMQW 370 TLTELLALEP 380 GVAYQHAFLY 390 IRQLAIHLRN 400 AMTTRKKETY 410 QSVYNWQYVH 420 CLFLWCRVLS 430 TAGPSEALQP 440 LVYPLAQVII 450 GCIKLIPTAR 460 FYPLRMHCIR 470 ALTLLSGSSG 480 AFIPVLPFIL 490 EMFQQVDFNR 500 KPGRMSSKPI 510 NFSVILKLSN 520 VNLQEKAYRD 530 GLVEQLYDLT 540 LEYLHSQAHC 550 IGFPELVLPV 560 VLQLKSFLRE 570 CKVANYCRQV 580 QQLLGKVQEN 590 SAYICSRRQR 600 VSFGVSEQQA 610 VEAWEKLTRE 620 EGTPLTLYYS 630 HWRKLRDREI 640 QLEISGKERL 650 EDLNFPEIKR 660 RKMADRKDED 670 RKQFKDLFDL 680 NSSEEDDTEG 690 FSERGILRPL 700 STRHGVEDDE 710 EDEEEGEEDS 720 SNSEDGDPDA 730 EAGLAPGELQ 740 QLAQGPEDEL EDLQLSEDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0030690 Noc1p-Noc2p complex
Cellular Component GO:0030691 Noc2p-Noc3p complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0031491 nucleosome binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0002903 negative regulation of B cell apoptotic process
Biological Process GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0042273 ribosomal large subunit biogenesis
Biological Process GO:0045815 transcription initiation-coupled chromatin remodeling

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.