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Overview

Uniprot ID	Q9Y3X0
Protein Name	Coiled-coil domain-containing protein 9
Gene Name	CCDC9
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
355	KSSRPQAKAAPRAYS
63	RKGRSVEKENVAVES

Function

Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation

Protein Sequence

10 MAATLDLKSK 20 EEKDAELDKR 30 IEALRRKNEA 40 LIRRYQEIEE 50 DRKKAELEGV 60 AVTAPRKGRS 70 VEKENVAVES 80 EKNLGPSRRS 90 PGTPRPPGAS 100 KGGRTPPQQG 110 GRAGMGRASR 120 SWEGSPGEQP 130 RGGGAGGRGR 140 RGRGRGSPHL 150 SGAGDTSISD 160 RKSKEWEERR 170 RQNIEKMNEE 180 MEKIAEYERN 190 QREGVLEPNP 200 VRNFLDDPRR 210 RSGPLEESER 220 DRREESRRHG 230 RNWGGPDFER 240 VRCGLEHERQ 250 GRRAGLGSAG 260 DMTLSMTGRE 270 RSEYLRWKQE 280 REKIDQERLQ 290 RHRKPTGQWR 300 REWDAEKTDG 310 MFKDGPVPAH 320 EPSHRYDDQA 330 WARPPKPPTF 340 GEFLSQHKAE 350 ASSRRRRKSS 360 RPQAKAAPRA 370 YSDHDDRWET 380 KEGAASPAPE 390 TPQPTSPETS 400 PKETPMQPPE 410 IPAPAHRPPE 420 DEGEENEGEE 430 DEEWEDISED 440 EEEEEIEVEE 450 GDEEEPAQDH 460 QAPEAAPTGI 470 PCSEQAHGVP 480 FSPEEPLLEP 490 QAPGTPSSPF 500 SPPSGHQPVS 510 DWGEEVELNS 520 PRTTHLAGAL 530 SPGEAWPFES V

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035145	exon-exon junction complex
Molecular Function	GO:0003723	RNA binding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.