Search Results

Overview

Uniprot IDQ9Y448
Protein NameSmall kinetochore-associated protein
Gene NameKNSTRN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
110 TQTRATSKSLLPVRS
124 SKEVDVSKQLHSGGP
140 NDVTKITKLRRENGQ

Function

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257)

Protein Sequence

10 MAAPEAPPLD 20 RVFRTTWLST 30 ECDSHPLPPS 40 YRKFLFETQA 50 ADLAGGTTVA 60 AGNLLNESEK 70 DCGQDRRAPG 80 VQPCRLVTMT 90 SVVKTVYSLQ 100 PPSALSGGQP 110 ADTQTRATSK 120 SLLPVRSKEV 130 DVSKQLHSGG 140 PENDVTKITK 150 LRRENGQMKA 160 TDTATRRNVR 170 KGYKPLSKQK 180 SEEELKDKNQ 190 LLEAVNKQLH 200 QKLTETQGEL 210 KDLTQKVELL 220 EKFRDNCLAI 230 LESKGLDPAL 240 GSETLASRQE 250 STTDHMDSML 260 LLETLQEELK 270 LFNETAKKQM 280 EELQALKVKL 290 EMKEERVRFL 300 EQQTLCNNQV 310 NDLTTALKEM EQLLEM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0035371 microtubule plus-end
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005634 nucleus
Cellular Component GO:0001726 ruffle
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0051010 microtubule plus-end binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0051301 cell division
Biological Process GO:0016477 cell migration
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000070 mitotic sister chromatid segregation
Biological Process GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Biological Process GO:0007051 spindle organization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.