Search Results

Overview

Uniprot IDQ9Y450
Protein NameHBS1-like protein
Gene NameHBS1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
140 EATVSTGKIAKGKPV
143 VSTGKIAKGKPVDSQ
161 SESEIVPKVAKMTVS
164 EIVPKVAKMTVSGKK
236 SSTPAPVKKSGKLRQ
237 STPAPVKKSGKLRQQ
294 INKRTMHKYEQESKK
622 RLISVLNKSTGEVTK

Function

GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463)

Protein Sequence

10 MARHRNVRGY 20 NYDEDFEDDD 30 LYGQSVEDDY 40 CISPSTAAQF 50 IYSRRDKPSV 60 EPVEEYDYED 70 LKESSNSVSN 80 HQLSGFDQAR 90 LYSCLDHMRE 100 VLGDAVPDEI 110 LIEAVLKNKF 120 DVQKALSGVL 130 EQDRVQSLKD 140 KNEATVSTGK 150 IAKGKPVDSQ 160 TSRSESEIVP 170 KVAKMTVSGK 180 KQTMGFEVPG 190 VSSEENGHSF 200 HTPQKGPPIE 210 DAIASSDVLE 220 TASKSANPPH 230 TIQASEEQSS 240 TPAPVKKSGK 250 LRQQIDVKAE 260 LEKRQGGKQL 270 LNLVVIGHVD 280 AGKSTLMGHM 290 LYLLGNINKR 300 TMHKYEQESK 310 KAGKASFAYA 320 WVLDETGEER 330 ERGVTMDVGM 340 TKFETTTKVI 350 TLMDAPGHKD 360 FIPNMITGAA 370 QADVAVLVVD 380 ASRGEFEAGF 390 ETGGQTREHG 400 LLVRSLGVTQ 410 LAVAVNKMDQ 420 VNWQQERFQE 430 ITGKLGHFLK 440 QAGFKESDVG 450 FIPTSGLSGE 460 NLITRSQSSE 470 LTKWYKGLCL 480 LEQIDSFKPP 490 QRSIDKPFRL 500 CVSDVFKDQG 510 SGFCITGKIE 520 AGYIQTGDRL 530 LAMPPNETCT 540 VKGITLHDEP 550 VDWAAAGDHV 560 SLTLVGMDII 570 KINVGCIFCG 580 PKVPIKACTR 590 FRARILIFNI 600 EIPITKGFPV 610 LLHYQTVSEP 620 AVIKRLISVL 630 NKSTGEVTKK 640 KPKFLTKGQN 650 ALVELQTQRP 660 IALELYKDFK 670 ELGRFMLRYG 680 GSTIAAGVVT EIKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:1990533 Dom34-Hbs1 complex
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
Biological Process GO:0006417 regulation of translation
Biological Process GO:0072344 rescue of stalled cytosolic ribosome
Biological Process GO:0032790 ribosome disassembly
Biological Process GO:0007165 signal transduction
Biological Process GO:0006412 translation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.