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Overview

Uniprot ID	Q9Y483
Protein Name	Metal-response element-binding transcription factor 2
Gene Name	MTF2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
14	AGNSLVHKRSPLRRN
30	KTPTSLTKLSLQDGH
395	EVSNGIEKKGKKKSV

Function

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity)

Protein Sequence

10 MRDSTGAGNS 20 LVHKRSPLRR 30 NQKTPTSLTK 40 LSLQDGHKAK 50 KPACKFEEGQ 60 DVLARWSDGL 70 FYLGTIKKIN 80 ILKQSCFIIF 90 EDSSKSWVLW 100 KDIQTGATGS 110 GEMVCTICQE 120 EYSEAPNEMV 130 ICDKCGQGYH 140 QLCHTPHIDS 150 SVIDSDEKWL 160 CRQCVFATTT 170 KRGGALKKGP 180 NAKALQVMKQ 190 TLPYSVADLE 200 WDAGHKTNVQ 210 QCYCYCGGPG 220 DWYLKMLQCC 230 KCKQWFHEAC 240 VQCLQKPMLF 250 GDRFYTFICS 260 VCSSGPEYLK 270 RLPLQWVDIA 280 HLCLYNLSVI 290 HKKKYFDSEL 300 ELMTYINENW 310 DRLHPGELAD 320 TPKSERYEHV 330 LEALNDYKTM 340 FMSGKEIKKK 350 KHLFGLRIRV 360 PPVPPNVAFK 370 AEKEPEGTSH 380 EFKIKGRKAS 390 KPISDSREVS 400 NGIEKKGKKK 410 SVGRPPGPYT 420 RKMIQKTAEP 430 LLDKESISEN 440 PTLDLPCSIG 450 RTEGTAHSSN 460 TSDVDFTGAS 470 SAKETTSSSI 480 SRHYGLSDSR 490 KRTRTGRSWP 500 AAIPHLRRRR 510 GRLPRRALQT 520 QNSEIVKDDE 530 GKEDYQFDEL 540 NTEILNNLAD 550 QELQLNHLKN 560 SITSYFGAAG 570 RIACGEKYRV 580 LARRVTLDGK 590 VQYLVEWEGA TAS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0035098	ESC/E(Z) complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0140003	histone H3K36me3 reader activity
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0001222	transcription corepressor binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0040029	epigenetic regulation of gene expression
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0007379	segment specification
Biological Process	GO:0048863	stem cell differentiation
Biological Process	GO:0019827	stem cell population maintenance

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.