Search Results

Overview

Uniprot IDQ9Y490
Protein NameTalin-1
Gene NameTLN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1068 EKDLQEVKAAARDGK
1170 SSLIEEAKKAAGHPG
1171 SLIEEAKKAAGHPGD
1190 QRLAQVAKAVTQALN
1306 AQVVSNLKGISMSSS
1320 SKLLLAAKALSTDPA
149 TGTLRKDKTLLRDEK
1541 NSTANLVKTIKALDG
1544 ANLVKTIKALDGAFT
164 KMEKLKQKLHTDDEL
1862 TTMVRTAKAIAVTVQ
1901 GRLASEAKPAAVAAE
1917 EEIGSHIKHRVQELG
196 ETLLLRRKFFYSDQN
1960 CARRVSEKVSHVLAA
2024 EGILKTAKVLVEDTK
2099 GDLISATKAAAGKVG
2130 TNVTSLLKTVKAVED
2133 TSLLKTVKAVEDEAT
2168 CSPEPPAKTSTPEDF
2188 GITMATAKAVAAGNS
2220 ADMLRACKEAAYHPE
2322 AIEAAAKKLEQLKPR
2331 EQLKPRAKPKEADES
2333 LKPRAKPKEADESLN
2443 AQLLVACKVKADQDS
2464 QAAGNAVKRASDNLV
2491 ENETVVVKEKMVGGI
2531 QIRQQQYKFLPSELR
357 EWNLTNIKRWAASPK
406 ILKKKKSKDHFGLEG
428 EDSVSPKKSTVLQQQ
441 QQYNRVGKVEHGSVA
685 AAAALVLKAKSVAQR
687 AALVLKAKSVAQRTE
786 NELLQHVKAHATGAG
910 AAAQNAIKKKLVQRL
911 AAQNAIKKKLVQRLE
922 QRLEHAAKQAAASAT

Function

High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims

Protein Sequence

10 MVALSLKISI 20 GNVVKTMQFE 30 PSTMVYDACR 40 IIRERIPEAP 50 AGPPSDFGLF 60 LSDDDPKKGI 70 WLEAGKALDY 80 YMLRNGDTME 90 YRKKQRPLKI 100 RMLDGTVKTI 110 MVDDSKTVTD 120 MLMTICARIG 130 ITNHDEYSLV 140 RELMEEKKEE 150 ITGTLRKDKT 160 LLRDEKKMEK 170 LKQKLHTDDE 180 LNWLDHGRTL 190 REQGVEEHET 200 LLLRRKFFYS 210 DQNVDSRDPV 220 QLNLLYVQAR 230 DDILNGSHPV 240 SFDKACEFAG 250 FQCQIQFGPH 260 NEQKHKAGFL 270 DLKDFLPKEY 280 VKQKGERKIF 290 QAHKNCGQMS 300 EIEAKVRYVK 310 LARSLKTYGV 320 SFFLVKEKMK 330 GKNKLVPRLL 340 GITKECVMRV 350 DEKTKEVIQE 360 WNLTNIKRWA 370 ASPKSFTLDF 380 GDYQDGYYSV 390 QTTEGEQIAQ 400 LIAGYIDIIL 410 KKKKSKDHFG 420 LEGDEESTML 430 EDSVSPKKST 440 VLQQQYNRVG 450 KVEHGSVALP 460 AIMRSGASGP 470 ENFQVGSMPP 480 AQQQITSGQM 490 HRGHMPPLTS 500 AQQALTGTIN 510 SSMQAVQAAQ 520 ATLDDFDTLP 530 PLGQDAASKA 540 WRKNKMDESK 550 HEIHSQVDAI 560 TAGTASVVNL 570 TAGDPAETDY 580 TAVGCAVTTI 590 SSNLTEMSRG 600 VKLLAALLED 610 EGGSGRPLLQ 620 AAKGLAGAVS 630 ELLRSAQPAS 640 AEPRQNLLQA 650 AGNVGQASGE 660 LLQQIGESDT 670 DPHFQDALMQ 680 LAKAVASAAA 690 ALVLKAKSVA 700 QRTEDSGLQT 710 QVIAAATQCA 720 LSTSQLVACT 730 KVVAPTISSP 740 VCQEQLVEAG 750 RLVAKAVEGC 760 VSASQAATED 770 GQLLRGVGAA 780 ATAVTQALNE 790 LLQHVKAHAT 800 GAGPAGRYDQ 810 ATDTILTVTE 820 NIFSSMGDAG 830 EMVRQARILA 840 QATSDLVNAI 850 KADAEGESDL 860 ENSRKLLSAA 870 KILADATAKM 880 VEAAKGAAAH 890 PDSEEQQQRL 900 REAAEGLRMA 910 TNAAAQNAIK 920 KKLVQRLEHA 930 AKQAAASATQ 940 TIAAAQHAAS 950 TPKASAGPQP 960 LLVQSCKAVA 970 EQIPLLVQGV 980 RGSQAQPDSP 990 SAQLALIAAS 1000 QSFLQPGGKM 1010 VAAAKASVPT 1020 IQDQASAMQL 1030 SQCAKNLGTA 1040 LAELRTAAQK 1050 AQEACGPLEM 1060 DSALSVVQNL 1070 EKDLQEVKAA 1080 ARDGKLKPLP 1090 GETMEKCTQD 1100 LGNSTKAVSS 1110 AIAQLLGEVA 1120 QGNENYAGIA 1130 ARDVAGGLRS 1140 LAQAARGVAA 1150 LTSDPAVQAI 1160 VLDTASDVLD 1170 KASSLIEEAK 1180 KAAGHPGDPE 1190 SQQRLAQVAK 1200 AVTQALNRCV 1210 SCLPGQRDVD 1220 NALRAVGDAS 1230 KRLLSDSLPP 1240 STGTFQEAQS 1250 RLNEAAAGLN 1260 QAATELVQAS 1270 RGTPQDLARA 1280 SGRFGQDFST 1290 FLEAGVEMAG 1300 QAPSQEDRAQ 1310 VVSNLKGISM 1320 SSSKLLLAAK 1330 ALSTDPAAPN 1340 LKSQLAAAAR 1350 AVTDSINQLI 1360 TMCTQQAPGQ 1370 KECDNALREL 1380 ETVRELLENP 1390 VQPINDMSYF 1400 GCLDSVMENS 1410 KVLGEAMTGI 1420 SQNAKNGNLP 1430 EFGDAISTAS 1440 KALCGFTEAA 1450 AQAAYLVGVS 1460 DPNSQAGQQG 1470 LVEPTQFARA 1480 NQAIQMACQS 1490 LGEPGCTQAQ 1500 VLSAATIVAK 1510 HTSALCNSCR 1520 LASARTTNPT 1530 AKRQFVQSAK 1540 EVANSTANLV 1550 KTIKALDGAF 1560 TEENRAQCRA 1570 ATAPLLEAVD 1580 NLSAFASNPE 1590 FSSIPAQISP 1600 EGRAAMEPIV 1610 ISAKTMLESA 1620 GGLIQTARAL 1630 AVNPRDPPSW 1640 SVLAGHSRTV 1650 SDSIKKLITS 1660 MRDKAPGQLE 1670 CETAIAALNS 1680 CLRDLDQASL 1690 AAVSQQLAPR 1700 EGISQEALHT 1710 QMLTAVQEIS 1720 HLIEPLANAA 1730 RAEASQLGHK 1740 VSQMAQYFEP 1750 LTLAAVGAAS 1760 KTLSHPQQMA 1770 LLDQTKTLAE 1780 SALQLLYTAK 1790 EAGGNPKQAA 1800 HTQEALEEAV 1810 QMMTEAVEDL 1820 TTTLNEAASA 1830 AGVVGGMVDS 1840 ITQAINQLDE 1850 GPMGEPEGSF 1860 VDYQTTMVRT 1870 AKAIAVTVQE 1880 MVTKSNTSPE 1890 ELGPLANQLT 1900 SDYGRLASEA 1910 KPAAVAAENE 1920 EIGSHIKHRV 1930 QELGHGCAAL 1940 VTKAGALQCS 1950 PSDAYTKKEL 1960 IECARRVSEK 1970 VSHVLAALQA 1980 GNRGTQACIT 1990 AASAVSGIIA 2000 DLDTTIMFAT 2010 AGTLNREGTE 2020 TFADHREGIL 2030 KTAKVLVEDT 2040 KVLVQNAAGS 2050 QEKLAQAAQS 2060 SVATITRLAD 2070 VVKLGAASLG 2080 AEDPETQVVL 2090 INAVKDVAKA 2100 LGDLISATKA 2110 AAGKVGDDPA 2120 VWQLKNSAKV 2130 MVTNVTSLLK 2140 TVKAVEDEAT 2150 KGTRALEATT 2160 EHIRQELAVF 2170 CSPEPPAKTS 2180 TPEDFIRMTK 2190 GITMATAKAV 2200 AAGNSCRQED 2210 VIATANLSRR 2220 AIADMLRACK 2230 EAAYHPEVAP 2240 DVRLRALHYG 2250 RECANGYLEL 2260 LDHVLLTLQK 2270 PSPELKQQLT 2280 GHSKRVAGSV 2290 TELIQAAEAM 2300 KGTEWVDPED 2310 PTVIAENELL 2320 GAAAAIEAAA 2330 KKLEQLKPRA 2340 KPKEADESLN 2350 FEEQILEAAK 2360 SIAAATSALV 2370 KAASAAQREL 2380 VAQGKVGAIP 2390 ANALDDGQWS 2400 QGLISAARMV 2410 AAATNNLCEA 2420 ANAAVQGHAS 2430 QEKLISSAKQ 2440 VAASTAQLLV 2450 ACKVKADQDS 2460 EAMKRLQAAG 2470 NAVKRASDNL 2480 VKAAQKAAAF 2490 EEQENETVVV 2500 KEKMVGGIAQ 2510 IIAAQEEMLR 2520 KERELEEARK 2530 KLAQIRQQQY 2540 KFLPSELRDE H

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0009986 cell surface
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001726 ruffle
Cellular Component GO:0032587 ruffle membrane
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0030274 LIM domain binding
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0001786 phosphatidylserine binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0017166 vinculin binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0043622 cortical microtubule organization
Biological Process GO:0033622 integrin activation
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0051893 regulation of focal adhesion assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.