Search Results

Overview

Uniprot IDQ9Y4A5
Protein NameTransformation/transcription domain-associated protein
Gene NameTRRAP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2059 VDSAQEVKRFRTATG

Function

Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity)

Protein Sequence

10 MAFVATQGAT 20 VVDQTTLMKK 30 YLQFVAALTD 40 VNTPDETKLK 50 MMQEVSENFE 60 NVTSSPQYST 70 FLEHIIPRFL 80 TFLQDGEVQF 90 LQEKPAQQLR 100 KLVLEIIHRI 110 PTNEHLRPHT 120 KNVLSVMFRF 130 LETENEENVL 140 ICLRIIIELH 150 KQFRPPITQE 160 IHHFLDFVKQ 170 IYKELPKVVN 180 RYFENPQVIP 190 ENTVPPPEMV 200 GMITTIAVKV 210 NPEREDSETR 220 THSIIPRGSL 230 SLKVLAELPI 240 IVVLMYQLYK 250 LNIHNVVAEF 260 VPLIMNTIAI 270 QVSAQARQHK 280 LYNKELYADF 290 IAAQIKTLSF 300 LAYIIRIYQE 310 LVTKYSQQMV 320 KGMLQLLSNC 330 PAETAHLRKE 340 LLIAAKHILT 350 TELRNQFIPC 360 MDKLFDESIL 370 IGSGYTARET 380 LRPLAYSTLA 390 DLVHHVRQHL 400 PLSDLSLAVQ 410 LFAKNIDDES 420 LPSSIQTMSC 430 KLLLNLVDCI 440 RSKSEQESGN 450 GRDVLMRMLE 460 VFVLKFHTIA 470 RYQLSAIFKK 480 CKPQSELGAV 490 EAALPGVPTA 500 PAAPGPAPSP 510 APVPAPPPPP 520 PPPPPATPVT 530 PAPVPPFEKQ 540 GEKDKEDKQT 550 FQVTDCRSLV 560 KTLVCGVKTI 570 TWGITSCKAP 580 GEAQFIPNKQ 590 LQPKETQIYI 600 KLVKYAMQAL 610 DIYQVQIAGN 620 GQTYIRVANC 630 QTVRMKEEKE 640 VLEHFAGVFT 650 MMNPLTFKEI 660 FQTTVPYMVE 670 RISKNYALQI 680 VANSFLANPT 690 TSALFATILV 700 EYLLDRLPEM 710 GSNVELSNLY 720 LKLFKLVFGS 730 VSLFAAENEQ 740 MLKPHLHKIV 750 NSSMELAQTA 760 KEPYNYFLLL 770 RALFRSIGGG 780 SHDLLYQEFL 790 PLLPNLLQGL 800 NMLQSGLHKQ 810 HMKDLFVELC 820 LTVPVRLSSL 830 LPYLPMLMDP 840 LVSALNGSQT 850 LVSQGLRTLE 860 LCVDNLQPDF 870 LYDHIQPVRA 880 ELMQALWRTL 890 RNPADSISHV 900 AYRVLGKFGG 910 SNRKMLKESQ 920 KLHYVVTEVQ 930 GPSITVEFSD 940 CKASLQLPME 950 KAIETALDCL 960 KSANTEPYYR 970 RQAWEVIKCF 980 LVAMMSLEDN 990 KHALYQLLAH 1000 PNFTEKTIPN 1010 VIISHRYKAQ 1020 DTPARKTFEQ 1030 ALTGAFMSAV 1040 IKDLRPSALP 1050 FVASLIRHYT 1060 MVAVAQQCGP 1070 FLLPCYQVGS 1080 QPSTAMFHSE 1090 ENGSKGMDPL 1100 VLIDAIAICM 1110 AYEEKELCKI 1120 GEVALAVIFD 1130 VASIILGSKE 1140 RACQLPLFSY 1150 IVERLCACCY 1160 EQAWYAKLGG 1170 VVSIKFLMER 1180 LPLTWVLQNQ 1190 QTFLKALLFV 1200 MMDLTGEVSN 1210 GAVAMAKTTL 1220 EQLLMRCATP 1230 LKDEERAEEI 1240 VAAQEKSFHH 1250 VTHDLVREVT 1260 SPNSTVRKQA 1270 MHSLQVLAQV 1280 TGKSVTVIME 1290 PHKEVLQDMV 1300 PPKKHLLRHQ 1310 PANAQIGLME 1320 GNTFCTTLQP 1330 RLFTMDLNVV 1340 EHKVFYTELL 1350 NLCEAEDSAL 1360 TKLPCYKSLP 1370 SLVPLRIAAL 1380 NALAACNYLP 1390 QSREKIIAAL 1400 FKALNSTNSE 1410 LQEAGEACMR 1420 KFLEGATIEV 1430 DQIHTHMRPL 1440 LMMLGDYRSL 1450 TLNVVNRLTS 1460 VTRLFPNSFN 1470 DKFCDQMMQH 1480 LRKWMEVVVI 1490 THKGGQRSDG 1500 NESISECGRC 1510 PLSPFCQFEE 1520 MKICSAIINL 1530 FHLIPAAPQT 1540 LVKPLLEVVM 1550 KTERAMLIEA 1560 GSPFREPLIK 1570 FLTRHPSQTV 1580 ELFMMEATLN 1590 DPQWSRMFMS 1600 FLKHKDARPL 1610 RDVLAANPNR 1620 FITLLLPGGA 1630 QTAVRPGSPS 1640 TSTMRLDLQF 1650 QAIKIISIIV 1660 KNDDSWLASQ 1670 HSLVSQLRRV 1680 WVSENFQERH 1690 RKENMAATNW 1700 KEPKLLAYCL 1710 LNYCKRNYGD 1720 IELLFQLLRA 1730 FTGRFLCNMT 1740 FLKEYMEEEI 1750 PKNYSIAQKR 1760 ALFFRFVDFN 1770 DPNFGDELKA 1780 KVLQHILNPA 1790 FLYSFEKGEG 1800 EQLLGPPNPE 1810 GDNPESITSV 1820 FITKVLDPEK 1830 QADMLDSLRI 1840 YLLQYATLLV 1850 EHAPHHIHDN 1860 NKNRNSKLRR 1870 LMTFAWPCLL 1880 SKACVDPACK 1890 YSGHLLLAHI 1900 IAKFAIHKKI 1910 VLQVFHSLLK 1920 AHAMEARAIV 1930 RQAMAILTPA 1940 VPARMEDGHQ 1950 MLTHWTRKII 1960 VEEGHTVPQL 1970 VHILHLIVQH 1980 FKVYYPVRHH 1990 LVQHMVSAMQ 2000 RLGFTPSVTI 2010 EQRRLAVDLS 2020 EVVIKWELQR 2030 IKDQQPDSDM 2040 DPNSSGEGVN 2050 SVSSSIKRGL 2060 SVDSAQEVKR 2070 FRTATGAISA 2080 VFGRSQSLPG 2090 ADSLLAKPID 2100 KQHTDTVVNF 2110 LIRVACQVND 2120 NTNTAGSPGE 2130 VLSRRCVNLL 2140 KTALRPDMWP 2150 KSELKLQWFD 2160 KLLMTVEQPN 2170 QVNYGNICTG 2180 LEVLSFLLTV 2190 LQSPAILSSF 2200 KPLQRGIAAC 2210 MTCGNTKVLR 2220 AVHSLLSRLM 2230 SIFPTEPSTS 2240 SVASKYEELE 2250 CLYAAVGKVI 2260 YEGLTNYEKA 2270 TNANPSQLFG 2280 TLMILKSACS 2290 NNPSYIDRLI 2300 SVFMRSLQKM 2310 VREHLNPQAA 2320 SGSTEATSGT 2330 SELVMLSLEL 2340 VKTRLAVMSM 2350 EMRKNFIQAI 2360 LTSLIEKSPD 2370 AKILRAVVKI 2380 VEEWVKNNSP 2390 MAANQTPTLR 2400 EKSILLVKMM 2410 TYIEKRFPED 2420 LELNAQFLDL 2430 VNYVYRDETL 2440 SGSELTAKLE 2450 PAFLSGLRCA 2460 QPLIRAKFFE 2470 VFDNSMKRRV 2480 YERLLYVTCS 2490 QNWEAMGNHF 2500 WIKQCIELLL 2510 AVCEKSTPIG 2520 TSCQGAMLPS 2530 ITNVINLADS 2540 HDRAAFAMVT 2550 HVKQEPRERE 2560 NSESKEEDVE 2570 IDIELAPGDQ 2580 TSTPKTKELS 2590 EKDIGNQLHM 2600 LTNRHDKFLD 2610 TLREVKTGAL 2620 LSAFVQLCHI 2630 STTLAEKTWV 2640 QLFPRLWKIL 2650 SDRQQHALAG 2660 EISPFLCSGS 2670 HQVQRDCQPS 2680 ALNCFVEAMS 2690 QCVPPIPIRP 2700 CVLKYLGKTH 2710 NLWFRSTLML 2720 EHQAFEKGLS 2730 LQIKPKQTTE 2740 FYEQESITPP 2750 QQEILDSLAE 2760 LYSLLQEEDM 2770 WAGLWQKRCK 2780 YSETATAIAY 2790 EQHGFFEQAQ 2800 ESYEKAMDKA 2810 KKEHERSNAS 2820 PAIFPEYQLW 2830 EDHWIRCSKE 2840 LNQWEALTEY 2850 GQSKGHINPY 2860 LVLECAWRVS 2870 NWTAMKEALV 2880 QVEVSCPKEM 2890 AWKVNMYRGY 2900 LAICHPEEQQ 2910 LSFIERLVEM 2920 ASSLAIREWR 2930 RLPHVVSHVH 2940 TPLLQAAQQI 2950 IELQEAAQIN 2960 AGLQPTNLGR 2970 NNSLHDMKTV 2980 VKTWRNRLPI 2990 VSDDLSHWSS 3000 IFMWRQHHYQ 3010 GKPTWSGMHS 3020 SSIVTAYENS 3030 SQHDPSSNNA 3040 MLGVHASASA 3050 IIQYGKIARK 3060 QGLVNVALDI 3070 LSRIHTIPTV 3080 PIVDCFQKIR 3090 QQVKCYLQLA 3100 GVMGKNECMQ 3110 GLEVIESTNL 3120 KYFTKEMTAE 3130 FYALKGMFLA 3140 QINKSEEANK 3150 AFSAAVQMHD 3160 VLVKAWAMWG 3170 DYLENIFVKE 3180 RQLHLGVSAI 3190 TCYLHACRHQ 3200 NESKSRKYLA 3210 KVLWLLSFDD 3220 DKNTLADAVD 3230 KYCIGVPPIQ 3240 WLAWIPQLLT 3250 CLVGSEGKLL 3260 LNLISQVGRV 3270 YPQAVYFPIR 3280 TLYLTLKIEQ 3290 RERYKSDPGP 3300 IRATAPMWRC 3310 SRIMHMQREL 3320 HPTLLSSLEG 3330 IVDQMVWFRE 3340 NWHEEVLRQL 3350 QQGLAKCYSV 3360 AFEKSGAVSD 3370 AKITPHTLNF 3380 VKKLVSTFGV 3390 GLENVSNVST 3400 MFSSAASESL 3410 ARRAQATAQD 3420 PVFQKLKGQF 3430 TTDFDFSVPG 3440 SMKLHNLISK 3450 LKKWIKILEA 3460 KTKQLPKFFL 3470 IEEKCRFLSN 3480 FSAQTAEVEI 3490 PGEFLMPKPT 3500 HYYIKIARFM 3510 PRVEIVQKHN 3520 TAARRLYIRG 3530 HNGKIYPYLV 3540 MNDACLTESR 3550 REERVLQLLR 3560 LLNPCLEKRK 3570 ETTKRHLFFT 3580 VPRVVAVSPQ 3590 MRLVEDNPSS 3600 LSLVEIYKQR 3610 CAKKGIEHDN 3620 PISRYYDRLA 3630 TVQARGTQAS 3640 HQVLRDILKE 3650 VQSNMVPRSM 3660 LKEWALHTFP 3670 NATDYWTFRK 3680 MFTIQLALIG 3690 FAEFVLHLNR 3700 LNPEMLQIAQ 3710 DTGKLNVAYF 3720 RFDINDATGD 3730 LDANRPVPFR 3740 LTPNISEFLT 3750 TIGVSGPLTA 3760 SMIAVARCFA 3770 QPNFKVDGIL 3780 KTVLRDEIIA 3790 WHKKTQEDTS 3800 SPLSAAGQPE 3810 NMDSQQLVSL 3820 VQKAVTAIMT 3830 RLHNLAQFEG 3840 GESKVNTLVA 3850 AANSLDNLCR MDPAWHPWL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035267 NuA4 histone acetyltransferase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000124 SAGA complex
Cellular Component GO:0000812 Swr1 complex
Cellular Component GO:0033276 transcription factor TFTC complex
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0140861 DNA repair-dependent chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:1905168 positive regulation of double-strand break repair via homologous recombination
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0006282 regulation of DNA repair
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:2000779 regulation of double-strand break repair
Biological Process GO:0043484 regulation of RNA splicing
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

PMID: N/A