Search Results

Overview

Uniprot IDQ9Y4B4
Protein NameHelicase ARIP4
Gene NameRAD54L2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
115 HMRRNIRKLLREDQL
423 FATGRPKKTKKRSHP
91 QLRRHQGKNLASEDP

Function

Helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner (By similarity). May stimulate the release of RNA polymerase II, that has paused near the transcription start sites of AR-targeted genes and unwind R-loops formed at these sites; R-loops result from the hybridization of the short RNA strand nascently synthesized by the paused RNA polymerase II molecule and the DNA template (PubMed:39028815). May also stimulate double-strand break formation by TOP2B, which appears important for transcriptional output (PubMed:39028815). Not able to remodel mononucleosomes in vitro (By similarity)

Protein Sequence

10 MSDESASGSD 20 PDLDPDVELE 30 DAEEEEEEEE 40 VAVEECDRDD 50 EEDLLDDPSL 60 EGMCGTEHAQ 70 LGEDGQQPPR 80 CTSTTSSQSE 90 PSEQLRRHQG 100 KNLASEDPKK 110 KRAQKPSHMR 120 RNIRKLLRED 130 QLEPVTKAAQ 140 QEELERRKRL 150 EQQRKDYAAP 160 IPTVPLEFLP 170 EEIALRASDG 180 PQLPPRVLAQ 190 EVICLDSSSG 200 SEDEKSSRDE 210 VIELSSGEED 220 TLHIVDSSES 230 VSEDDEEEEK 240 GGTHVNDVLN 250 QRDALGRVLV 260 NLNHPPEEEN 270 VFLAPQLARA 280 VKPHQIGGIR 290 FLYDNLVESL 300 ERFKTSSGFG 310 CILAHSMGLG 320 KTLQVISFID 330 VLFRHTPAKT 340 VLAIVPVNTL 350 QNWLAEFNMW 360 LPPPEALPAD 370 NKPEEVQPRF 380 FKVHILNDEH 390 KTMASRAKVM 400 ADWVSEGGVL 410 LMGYEMYRLL 420 TLKKSFATGR 430 PKKTKKRSHP 440 VIIDLDEEDR 450 QQEFRREFEK 460 ALCRPGPDVV 470 ICDEGHRIKN 480 CQASTSQALK 490 NIRSRRRVVL 500 TGYPLQNNLI 510 EYWCMVDFVR 520 PDFLGTRQEF 530 SNMFERPILN 540 GQCIDSTPQD 550 VRLMRYRSHV 560 LHSLLEGFVQ 570 RRGHTVLKIH 580 LPAKEENVIL 590 VRLSKIQRDL 600 YTQFMDRFRD 610 CGSSGWLGLN 620 PLKAFCVCCK 630 IWNHPDVLYE 640 ALQKESLANE 650 QDLDVEELGS 660 AGTSARCPPQ 670 GTKGKGEDST 680 LASSMGEATN 690 SKFLQGVGFN 700 PFQERGNNIV 710 TYEWAKDLLT 720 NYQTGVLENS 730 PKMVLLFHLI 740 EESVKLGDKI 750 LVFSQSLSTL 760 ALIEEFLGKR 770 EVPCPPGTEG 780 QGAQKWVRNI 790 SYFRLDGSTP 800 AFERERLINQ 810 FNDPSNLTTW 820 LFLLSTRAGC 830 LGVNLIGANR 840 VVVFDASWNP 850 CHDAQAVCRV 860 YRYGQKKPCY 870 IYRLVADYTL 880 EKKIYDRQIS 890 KQGMSDRVVD 900 DLNPMLNFTR 910 KEVENLLHFV 920 EKEPAPQVSL 930 NVKGIKESVL 940 QLACLKYPHL 950 ITKEPFEHES 960 LLLNRKDHKL 970 TKAEKKAAKK 980 SYEEDKRTSV 990 PYTRPSYAQY 1000 YPASDQSLTS 1010 IPAFSQRNWQ 1020 PTLKGDEKPV 1030 ASVRPVQSTP 1040 IPMMPRHVPL 1050 GGSVSSASST 1060 NPSMNFPINY 1070 LQRAGVLVQK 1080 VVTTTDIVIP 1090 GLNSSTDVQA 1100 RINAGESIHI 1110 IRGTKGTYIR 1120 TSDGRIFAVR 1130 ATGKPKVPED 1140 GRMAASGSQG 1150 PSCESTSNGR 1160 HSASSPKAPD 1170 PEGLARPVSP 1180 DSPEIISELQ 1190 QYADVAAARE 1200 SRQSSPSTNA 1210 ALPGPPAQLM 1220 DSSAVPGTAL 1230 GTEPRLGGHC 1240 LNSSLLVTGQ 1250 PCGDRHPVLD 1260 LRGHKRKLAT 1270 PPAAQESSRR 1280 RSRKGHLPAP 1290 VQPYEHGYPV 1300 SGGFAMPPVS 1310 LNHNLTTPFT 1320 SQAGENSLFM 1330 GSTPSYYQLS 1340 NLLADARLVF 1350 PVTTDPLVPA 1360 GPVSSSSTAT 1370 SVTASNPSFM 1380 LNPSVPGILP 1390 SYSLPFSQPL 1400 LSEPRMFAPF 1410 PSPVLPSNLS 1420 RGMSIYPGYM 1430 SPHAGYPAGG 1440 LLRSQVPPFD 1450 SHEVAEVGFS 1460 SNDDEDKDDD VIEVTGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Biological Process GO:0006325 chromatin organization
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0062176 R-loop processing
Biological Process GO:0006368 transcription elongation by RNA polymerase II
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0033677 DNA/RNA helicase activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0061630 ubiquitin protein ligase activity

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.