Search Results

Overview

Uniprot IDQ9Y4B5
Protein NameMicrotubule cross-linking factor 1
Gene NameMTCL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
124 ARAAGGAKAALGSRR
158 EPPSAAAKGRKAKRG

Function

Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225)

Protein Sequence

10 METLNGPAGG 20 GAPDAKLQPP 30 GQHHRHHHLH 40 PVAERRRLHR 50 APSPARPFLK 60 DLHARPAAPG 70 PAVPSSGRAP 80 APAAPRSPNL 90 AGKAPPSPGS 100 LAAPGRLSRR 110 SGGVPGAKDK 120 PPPGAGARAA 130 GGAKAALGSR 140 RAARVAPAEP 150 LSRAGKPPGA 160 EPPSAAAKGR 170 KAKRGSRAPP 180 ARTVGPPTPA 190 ARIPAVTLAV 200 TSVAGSPARC 210 SRISHTDSSS 220 DLSDCPSEPL 230 SDEQRLLPAA 240 SSDAESGTGS 250 SDREPPRGAP 260 TPSPAARGAP 270 PGSPEPPALL 280 AAPLAAGACP 290 GGRSIPSGVS 300 GGFAGPGVAE 310 DVRGRSPPER 320 PVPGTPKEPS 330 LGEQSRLVPA 340 AEEEELLREM 350 EELRSENDYL 360 KDELDELRAE 370 MEEMRDSYLE 380 EDVYQLQELR 390 RELDRANKNC 400 RILQYRLRKA 410 EQKSLKVAET 420 GQVDGELIRS 430 LEQDLKVAKD 440 VSVRLHHELK 450 TVEEKRAKAE 460 DENETLRQQM 470 IEVEISKQAL 480 QNELERLKES 490 SLKRRSTREM 500 YKEKKTFNQD 510 DSADLRCQLQ 520 FAKEEAFLMR 530 KKMAKLGREK 540 DELEQELQKY 550 KSLYGDVDSP 560 LPTGEAGGPP 570 STREAELKLR 580 LKLVEEEANI 590 LGRKIVELEV 600 ENRGLKAEME 610 DMRGQQEREG 620 PGRDHAPSIP 630 TSPFGDSLES 640 STELRRHLQF 650 VEEEAELLRR 660 SISEIEDHNR 670 QLTHELSKFK 680 FEPPREPGWL 690 GEGASPGAGG 700 GAPLQEELKS 710 ARLQISELSG 720 KVLKLQHENH 730 ALLSNIQRCD 740 LAAHLGLRAP 750 SPRDSDAESD 760 AGKKESDGEE 770 SRLPQPKREG 780 PVGGESDSEE 790 MFEKTSGFGS 800 GKPSEASEPC 810 PTELLKARED 820 SEYLVTLKHE 830 AQRLERTVER 840 LITDTDSFLH 850 DAGLRGGAPL 860 PGPGLQGEEE 870 QGEGDQQEPQ 880 LLGTINAKMK 890 AFKKELQAFL 900 EQVNRIGDGL 910 SPLPHLTESS 920 SFLSTVTSVS 930 RDSPIGNLGK 940 ELGPDLQSRL 950 KEQLEWQLGP 960 ARGDERESLR 970 LRAARELHRR 980 ADGDTGSHGL 990 GGQTCFSLEM 1000 EEEHLYALRW 1010 KELEMHSLAL 1020 QNTLHERTWS 1030 DEKNLMQQEL 1040 RSLKQNIFLF 1050 YVKLRWLLKH 1060 WRQGKQMEEE 1070 GEEFTEGEHP 1080 ETLSRLGELG 1090 VQGGHQADGP 1100 DHDSDRGCGF 1110 PVGEHSPHSR 1120 VQIGDHSLRL 1130 QTADRGQPHK 1140 QVVENQQLFS 1150 AFKALLEDFR 1160 AELREDERAR 1170 LRLQQQYASD 1180 KAAWDVEWAV 1190 LKCRLEQLEE 1200 KTENKLGELG 1210 SSAESKGALK 1220 KEREVHQKLL 1230 ADSHSLVMDL 1240 RWQIHHSEKN 1250 WNREKVELLD 1260 RLDRDRQEWE 1270 RQKKEFLWRI 1280 EQLQKENSPR 1290 RGGSFLCDQK 1300 DGNVRPFPHQ 1310 GSLRMPRPVA 1320 MWPCADADSI 1330 PFEDRPLSKL 1340 KESDRCSASE 1350 NLYLDALSLD 1360 DEPEEPPAHR 1370 PEREFRNRLP 1380 EEEENHKGNL 1390 QRAVSVSSMS 1400 EFQRLMDISP 1410 FLPEKGLPST 1420 SSKEDVTPPL 1430 SPDDLKYIEE 1440 FNKSWDYTPN 1450 RGHNGGGPDL 1460 WADRTEVGRA 1470 GHEDSTEPFP 1480 DSSWYLTTSV 1490 TMTTDTMTSP 1500 EHCQKQPLRS 1510 HVLTEQSGLR 1520 VLHSPPAVRR 1530 VDSITAAGGE 1540 GPFPTSRARG 1550 SPGDTKGGPP 1560 EPMLSRWPCT 1570 SPRHSRDYVE 1580 GARRPLDSPL 1590 CTSLGFASPL 1600 HSLEMSKNLS 1610 DDMKEVAFSV 1620 RNAICSGPGE 1630 LQVKDMACQT 1640 NGSRTMGTQT 1650 VQTISVGLQT 1660 EALRGSGVTS 1670 SPHKCLTPKA 1680 GGGATPVSSP 1690 SRSLRSRQVA 1700 PAIEKVQAKF 1710 ERTCCSPKYG 1720 SPKLQRKPLP 1730 KADQPNNRTS 1740 PGMAQKGYSE 1750 SAWARSTTTR 1760 ESPVHTTIND 1770 GLSSLFNIID 1780 HSPVVQDPFQ 1790 KGLRAGSRSR 1800 SAEPRPELGP 1810 GQETGTNSRG 1820 RSPSPIGVGS 1830 EMCREEGGEG 1840 TPVKQDLSAP 1850 PGYTLTENVA 1860 RILNKKLLEH 1870 ALKEERRQAA 1880 HGPPGLHSDS 1890 HSLGDTAEPG 1900 PMENQTVLLT APWGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0097427 microtubule bundle
Cellular Component GO:0030496 midbody
Cellular Component GO:0005876 spindle microtubule
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0051301 cell division
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0001578 microtubule bundle formation
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0010506 regulation of autophagy

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.