Search Results
Overview
| Uniprot ID | Q9Y4C1 |
|---|---|
| Protein Name | Lysine-specific demethylase 3A |
| Gene Name | KDM3A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 312 | TAATPPSKDPRQQST |
| 371 | CKAGLLSKSSQIGTG |
| 503 | CCSRSNNKIQNAPSR |
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1
Protein Sequence
10
MVLTLGESWP
20
VLVGRRFLSL
30
SAADGSDGSH
40
DSWDVERVAE
50
WPWLSGTIRA
60
VSHTDVTKKD
70
LKVCVEFDGE
80
SWRKRRWIEV
90
YSLLRRAFLV
100
EHNLVLAERK
110
SPEISERIVQ
120
WPAITYKPLL
130
DKAGLGSITS
140
VRFLGDQQRV
150
FLSKDLLKPI
160
QDVNSLRLSL
170
TDNQIVSKEF
180
QALIVKHLDE
190
SHLLKGDKNL
200
VGSEVKIYSL
210
DPSTQWFSAT
220
VINGNPASKT
230
LQVNCEEIPA
240
LKIVDPSLIH
250
VEVVHDNLVT
260
CGNSARIGAV
270
KRKSSENNGT
280
LVSKQAKSCS
290
EASPSMCPVQ
300
SVPTTVFKEI
310
LLGCTAATPP
320
SKDPRQQSTP
330
QAANSPPNLG
340
AKIPQGCHKQ
350
SLPEEISSCL
360
NTKSEALRTK
370
PDVCKAGLLS
380
KSSQIGTGDL
390
KILTEPKGSC
400
TQPKTNTDQE
410
NRLESVPQAL
420
TGLPKECLPT
430
KASSKAELEI
440
ANPPELQKHL
450
EHAPSPSDVS
460
NAPEVKAGVN
470
SDSPNNCSGK
480
KVEPSALACR
490
SQNLKESSVK
500
VDNESCCSRS
510
NNKIQNAPSR
520
KSVLTDPAKL
530
KKLQQSGEAF
540
VQDDSCVNIV
550
AQLPKCRECR
560
LDSLRKDKEQ
570
QKDSPVFCRF
580
FHFRRLQFNK
590
HGVLRVEGFL
600
TPNKYDNEAI
610
GLWLPLTKNV
620
VGIDLDTAKY
630
ILANIGDHFC
640
QMVISEKEAM
650
STIEPHRQVA
660
WKRAVKGVRE
670
MCDVCDTTIF
680
NLHWVCPRCG
690
FGVCVDCYRM
700
KRKNCQQGAA
710
YKTFSWLKCV
720
KSQIHEPENL
730
MPTQIIPGKA
740
LYDVGDIVHS
750
VRAKWGIKAN
760
CPCSNRQFKL
770
FSKPASKEDL
780
KQTSLAGEKP
790
TLGAVLQQNP
800
SVLEPAAVGG
810
EAASKPAGSM
820
KPACPASTSP
830
LNWLADLTSG
840
NVNKENKEKQ
850
PTMPILKNEI
860
KCLPPLPPLS
870
KSSTVLHTFN
880
STILTPVSNN
890
NSGFLRNLLN
900
SSTGKTENGL
910
KNTPKILDDI
920
FASLVQNKTT
930
SDLSKRPQGL
940
TIKPSILGFD
950
TPHYWLCDNR
960
LLCLQDPNNK
970
SNWNVFRECW
980
KQGQPVMVSG
990
VHHKLNSELW
1000
KPESFRKEFG
1010
EQEVDLVNCR
1020
TNEIITGATV
1030
GDFWDGFEDV
1040
PNRLKNEKEP
1050
MVLKLKDWPP
1060
GEDFRDMMPS
1070
RFDDLMANIP
1080
LPEYTRRDGK
1090
LNLASRLPNY
1100
FVRPDLGPKM
1110
YNAYGLITPE
1120
DRKYGTTNLH
1130
LDVSDAANVM
1140
VYVGIPKGQC
1150
EQEEEVLKTI
1160
QDGDSDELTI
1170
KRFIEGKEKP
1180
GALWHIYAAK
1190
DTEKIREFLK
1200
KVSEEQGQEN
1210
PADHDPIHDQ
1220
SWYLDRSLRK
1230
RLHQEYGVQG
1240
WAIVQFLGDV
1250
VFIPAGAPHQ
1260
VHNLYSCIKV
1270
AEDFVSPEHV
1280
KHCFWLTQEF
1290
RYLSQTHTNH
1300
EDKLQVKNVI
1310
YHAVKDAVAM
1320
LKASESSFGK
P
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0032454 | histone H3K9 demethylase activity |
| Molecular Function | GO:0140683 | histone H3K9me/H3K9me2 demethylase activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0050681 | nuclear androgen receptor binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030521 | androgen receptor signaling pathway |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0046293 | formaldehyde biosynthetic process |
| Biological Process | GO:0009755 | hormone-mediated signaling pathway |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
PMID: N/A