Search Results

Overview

Uniprot IDQ9Y4D7
Protein NamePlexin-D1
Gene NamePLXND1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
126 RLTDNYNKILQLDPG

Function

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E

Protein Sequence

10 MAPRAAGGAP 20 LSARAAAASP 30 PPFQTPPRCP 40 VPLLLLLLLG 50 AARAGALEIQ 60 RRFPSPTPTN 70 NFALDGAAGT 80 VYLAAVNRLY 90 QLSGANLSLE 100 AEAAVGPVPD 110 SPLCHAPQLP 120 QASCEHPRRL 130 TDNYNKILQL 140 DPGQGLVVVC 150 GSIYQGFCQL 160 RRRGNISAVA 170 VRFPPAAPPA 180 EPVTVFPSML 190 NVAANHPNAS 200 TVGLVLPPAA 210 GAGGSRLLVG 220 ATYTGYGSSF 230 FPRNRSLEDH 240 RFENTPEIAI 250 RSLDTRGDLA 260 KLFTFDLNPS 270 DDNILKIKQG 280 AKEQHKLGFV 290 SAFLHPSDPP 300 PGAQSYAYLA 310 LNSEARAGDK 320 ESQARSLLAR 330 ICLPHGAGGD 340 AKKLTESYIQ 350 LGLQCAGGAG 360 RGDLYSRLVS 370 VFPARERLFA 380 VFERPQGSPA 390 ARAAPAALCA 400 FRFADVRAAI 410 RAARTACFVE 420 PAPDVVAVLD 430 SVVQGTGPAC 440 ERKLNIQLQP 450 EQLDCGAAHL 460 QHPLSILQPL 470 KATPVFRAPG 480 LTSVAVASVN 490 NYTAVFLGTV 500 NGRLLKINLN 510 ESMQVVSRRV 520 VTVAYGEPVH 530 HVMQFDPADS 540 GYLYLMTSHQ 550 MARVKVAACN 560 VHSTCGDCVG 570 AADAYCGWCA 580 LETRCTLQQD 590 CTNSSQQHFW 600 TSASEGPSRC 610 PAMTVLPSEI 620 DVRQEYPGMI 630 LQISGSLPSL 640 SGMEMACDYG 650 NNIRTVARVP 660 GPAFGHQIAY 670 CNLLPRDQFP 680 PFPPNQDHVT 690 VEMSVRVNGR 700 NIVKANFTIY 710 DCSRTAQVYP 720 HTACTSCLSA 730 QWPCFWCSQQ 740 HSCVSNQSRC 750 EASPNPTSPQ 760 DCPRTLLSPL 770 APVPTGGSQN 780 ILVPLANTAF 790 FQGAALECSF 800 GLEEIFEAVW 810 VNESVVRCDQ 820 VVLHTTRKSQ 830 VFPLSLQLKG 840 RPARFLDSPE 850 PMTVMVYNCA 860 MGSPDCSQCL 870 GREDLGHLCM 880 WSDGCRLRGP 890 LQPMAGTCPA 900 PEIHAIEPLS 910 GPLDGGTLLT 920 IRGRNLGRRL 930 SDVAHGVWIG 940 GVACEPLPDR 950 YTVSEEIVCV 960 TGPAPGPLSG 970 VVTVNASKEG 980 KSRDRFSYVL 990 PLVHSLEPTM 1000 GPKAGGTRIT 1010 IHGNDLHVGS 1020 ELQVLVNDTD 1030 PCTELMRTDT 1040 SIACTMPEGA 1050 LPAPVPVCVR 1060 FERRGCVHGN 1070 LTFWYMQNPV 1080 ITAISPRRSP 1090 VSGGRTITVA 1100 GERFHMVQNV 1110 SMAVHHIGRE 1120 PTLCKVLNST 1130 LITCPSPGAL 1140 SNASAPVDFF 1150 INGRAYADEV 1160 AVAEELLDPE 1170 EAQRGSRFRL 1180 DYLPNPQFST 1190 AKREKWIKHH 1200 PGEPLTLVIH 1210 KEQDSLGLQS 1220 HEYRVKIGQV 1230 SCDIQIVSDR 1240 IIHCSVNESL 1250 GAAVGQLPIT 1260 IQVGNFNQTI 1270 ATLQLGGSET 1280 AIIVSIVICS 1290 VLLLLSVVAL 1300 FVFCTKSRRA 1310 ERYWQKTLLQ 1320 MEEMESQIRE 1330 EIRKGFAELQ 1340 TDMTDLTKEL 1350 NRSQGIPFLE 1360 YKHFVTRTFF 1370 PKCSSLYEER 1380 YVLPSQTLNS 1390 QGSSQAQETH 1400 PLLGEWKIPE 1410 SCRPNMEEGI 1420 SLFSSLLNNK 1430 HFLIVFVHAL 1440 EQQKDFAVRD 1450 RCSLASLLTI 1460 ALHGKLEYYT 1470 SIMKELLVDL 1480 IDASAAKNPK 1490 LMLRRTESVV 1500 EKMLTNWMSI 1510 CMYSCLRETV 1520 GEPFFLLLCA 1530 IKQQINKGSI 1540 DAITGKARYT 1550 LSEEWLLREN 1560 IEAKPRNLNV 1570 SFQGCGMDSL 1580 SVRAMDTDTL 1590 TQVKEKILEA 1600 FCKNVPYSQW 1610 PRAEDVDLEW 1620 FASSTQSYIL 1630 RDLDDTSVVE 1640 DGRKKLNTLA 1650 HYKIPEGASL 1660 AMSLIDKKDN 1670 TLGRVKDLDT 1680 EKYFHLVLPT 1690 DELAEPKKSH 1700 RQSHRKKVLP 1710 EIYLTRLLST 1720 KGTLQKFLDD 1730 LFKAILSIRE 1740 DKPPLAVKYF 1750 FDFLEEQAEK 1760 RGISDPDTLH 1770 IWKTNSLPLR 1780 FWVNILKNPQ 1790 FVFDIDKTDH 1800 IDACLSVIAQ 1810 AFIDACSISD 1820 LQLGKDSPTN 1830 KLLYAKEIPE 1840 YRKIVQRYYK 1850 QIQDMTPLSE 1860 QEMNAHLAEE 1870 SRKYQNEFNT 1880 NVAMAEIYKY 1890 AKRYRPQIMA 1900 ALEANPTARR 1910 TQLQHKFEQV 1920 VALMEDNIYE CYSEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0044297 cell body
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0031258 lamellipodium membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002116 semaphorin receptor complex
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0017154 semaphorin receptor activity
Biological Process GO:0001525 angiogenesis
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0050772 positive regulation of axonogenesis
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0071526 semaphorin-plexin signaling pathway
Biological Process GO:0007416 synapse assembly
Biological Process GO:0008039 synaptic target recognition

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.