Search Results

Overview

Uniprot IDQ9Y4G6
Protein NameTalin-2
Gene NameTLN2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2334 LKPRAKPKQADETLD
319 GVSFFLVKEKMKGKN

Function

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity)

Protein Sequence

10 MVALSLKICV 20 RHCNVVKTMQ 30 FEPSTAVYDA 40 CRVIRERVPE 50 AQTGQASDYG 60 LFLSDEDPRK 70 GIWLEAGRTL 80 DYYMLRNGDI 90 LEYKKKQRPQ 100 KIRMLDGSVK 110 TVMVDDSKTV 120 GELLVTICSR 130 IGITNYEEYS 140 LIQETIEEKK 150 EEGTGTLKKD 160 RTLLRDERKM 170 EKLKAKLHTD 180 DDLNWLDHSR 190 TFREQGVDEN 200 ETLLLRRKFF 210 YSDQNVDSRD 220 PVQLNLLYVQ 230 ARDDILNGSH 240 PVSFEKACEF 250 GGFQAQIQFG 260 PHVEHKHKPG 270 FLDLKEFLPK 280 EYIKQRGAEK 290 RIFQEHKNCG 300 EMSEIEAKVK 310 YVKLARSLRT 320 YGVSFFLVKE 330 KMKGKNKLVP 340 RLLGITKDSV 350 MRVDEKTKEV 360 LQEWPLTTVK 370 RWAASPKSFT 380 LDFGEYQESY 390 YSVQTTEGEQ 400 ISQLIAGYID 410 IILKKKQSKD 420 RFGLEGDEES 430 TMLEESVSPK 440 KSTILQQQFN 450 RTGKAEHGSV 460 ALPAVMRSGS 470 SGPETFNVGS 480 MPSPQQQVMV 490 GQMHRGHMPP 500 LTSAQQALMG 510 TINTSMHAVQ 520 QAQDDLSELD 530 SLPPLGQDMA 540 SRVWVQNKVD 550 ESKHEIHSQV 560 DAITAGTASV 570 VNLTAGDPAD 580 TDYTAVGCAI 590 TTISSNLTEM 600 SKGVKLLAAL 610 MDDEVGSGED 620 LLRAARTLAG 630 AVSDLLKAVQ 640 PTSGEPRQTV 650 LTAAGSIGQA 660 SGDLLRQIGE 670 NETDERFQDV 680 LMSLAKAVAN 690 AAAMLVLKAK 700 NVAQVAEDTV 710 LQNRVIAAAT 720 QCALSTSQLV 730 ACAKVVSPTI 740 SSPVCQEQLI 750 EAGKLVDRSV 760 ENCVRACQAA 770 TTDSELLKQV 780 SAAASVVSQA 790 LHDLLQHVRQ 800 FASRGEPIGR 810 YDQATDTIMC 820 VTESIFSSMG 830 DAGEMVRQAR 840 VLAQATSDLV 850 NAMRSDAEAE 860 IDMENSKKLL 870 AAAKLLADST 880 ARMVEAAKGA 890 AANPENEDQQ 900 QRLREAAEGL 910 RVATNAAAQN 920 AIKKKIVNRL 930 EVAAKQAAAA 940 ATQTIAASQN 950 AAVSNKNPAA 960 QQQLVQSCKA 970 VADHIPQLVQ 980 GVRGSQAQAE 990 DLSAQLALII 1000 SSQNFLQPGS 1010 KMVSSAKAAV 1020 PTVSDQAAAM 1030 QLSQCAKNLA 1040 TSLAELRTAS 1050 QKAHEACGPM 1060 EIDSALNTVQ 1070 TLKNELQDAK 1080 MAAVESQLKP 1090 LPGETLEKCA 1100 QDLGSTSKAV 1110 GSSMAQLLTC 1120 AAQGNEHYTG 1130 VAARETAQAL 1140 KTLAQAARGV 1150 AASTTDPAAA 1160 HAMLDSARDV 1170 MEGSAMLIQE 1180 AKQALIAPGD 1190 AERQQRLAQV 1200 AKAVSHSLNN 1210 CVNCLPGQKD 1220 VDVALKSIGE 1230 SSKKLLVDSL 1240 PPSTKPFQEA 1250 QSELNQAAAD 1260 LNQSAGEVVH 1270 ATRGQSGELA 1280 AASGKFSDDF 1290 DEFLDAGIEM 1300 AGQAQTKEDQ 1310 IQVIGNLKNI 1320 SMASSKLLLA 1330 AKSLSVDPGA 1340 PNAKNLLAAA 1350 ARAVTESINQ 1360 LITLCTQQAP 1370 GQKECDNALR 1380 ELETVKGMLD 1390 NPNEPVSDLS 1400 YFDCIESVME 1410 NSKVLGESMA 1420 GISQNAKTGD 1430 LPAFGECVGI 1440 ASKALCGLTE 1450 AAAQAAYLVG 1460 ISDPNSQAGH 1470 QGLVDPIQFA 1480 RANQAIQMAC 1490 QNLVDPGSSP 1500 SQVLSAATIV 1510 AKHTSALCNA 1520 CRIASSKTAN 1530 PVAKRHFVQS 1540 AKEVANSTAN 1550 LVKTIKALDG 1560 DFSEDNRNKC 1570 RIATAPLIEA 1580 VENLTAFASN 1590 PEFVSIPAQI 1600 SSEGSQAQEP 1610 ILVSAKTMLE 1620 SSSYLIRTAR 1630 SLAINPKDPP 1640 TWSVLAGHSH 1650 TVSDSIKSLI 1660 TSIRDKAPGQ 1670 RECDYSIDGI 1680 NRCIRDIEQA 1690 SLAAVSQSLA 1700 TRDDISVEAL 1710 QEQLTSVVQE 1720 IGHLIDPIAT 1730 AARGEAAQLG 1740 HKVTQLASYF 1750 EPLILAAVGV 1760 ASKILDHQQQ 1770 MTVLDQTKTL 1780 AESALQMLYA 1790 AKEGGGNPKA 1800 QHTHDAITEA 1810 AQLMKEAVDD 1820 IMVTLNEAAS 1830 EVGLVGGMVD 1840 AIAEAMSKLD 1850 EGTPPEPKGT 1860 FVDYQTTVVK 1870 YSKAIAVTAQ 1880 EMMTKSVTNP 1890 EELGGLASQM 1900 TSDYGHLAFQ 1910 GQMAAATAEP 1920 EEIGFQIRTR 1930 VQDLGHGCIF 1940 LVQKAGALQV 1950 CPTDSYTKRE 1960 LIECARAVTE 1970 KVSLVLSALQ 1980 AGNKGTQACI 1990 TAATAVSGII 2000 ADLDTTIMFA 2010 TAGTLNAENS 2020 ETFADHRENI 2030 LKTAKALVED 2040 TKLLVSGAAS 2050 TPDKLAQAAQ 2060 SSAATITQLA 2070 EVVKLGAASL 2080 GSDDPETQVV 2090 LINAIKDVAK 2100 ALSDLISATK 2110 GAASKPVDDP 2120 SMYQLKGAAK 2130 VMVTNVTSLL 2140 KTVKAVEDEA 2150 TRGTRALEAT 2160 IECIKQELTV 2170 FQSKDVPEKT 2180 SSPEESIRMT 2190 KGITMATAKA 2200 VAAGNSCRQE 2210 DVIATANLSR 2220 KAVSDMLTAC 2230 KQASFHPDVS 2240 DEVRTRALRF 2250 GTECTLGYLD 2260 LLEHVLVILQ 2270 KPTPEFKQQL 2280 AAFSKRVAGA 2290 VTELIQAAEA 2300 MKGTEWVDPE 2310 DPTVIAETEL 2320 LGAAASIEAA 2330 AKKLEQLKPR 2340 AKPKQADETL 2350 DFEEQILEAA 2360 KSIAAATSAL 2370 VKSASAAQRE 2380 LVAQGKVGSI 2390 PANAADDGQW 2400 SQGLISAARM 2410 VAAATSSLCE 2420 AANASVQGHA 2430 SEEKLISSAK 2440 QVAASTAQLL 2450 VACKVKADQD 2460 SEAMRRLQAA 2470 GNAVKRASDN 2480 LVRAAQKAAF 2490 GKADDDDVVV 2500 KTKFVGGIAQ 2510 IIAAQEEMLK 2520 KERELEEARK 2530 KLAQIRQQQY 2540 KFLPTELRED EG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001726 ruffle
Cellular Component GO:0045202 synapse
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007155 cell adhesion
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0099140 presynaptic actin cytoskeleton organization

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.